Summary
The amino acid compositions of several monomeric NADPH-dependent aldehyde reductases from a variety of species have been determined and analyzed by the difference index method of Metzger et al. (1968). The difference indexes among mammals range from 4.15 – 6.10 indicating considerable homology. Comparison of chicken aldehyde reductase with mammalian aldehyde reductases gave values in the range 6.8 – 9.9 suggesting a close relationship whereas the difference indexes for the enzymes from fruit fly and Baker's yeast versus vertebrate aldehyde reductases (10.9 – 14.4) indicate more distant relationships. The extent of sequence homology among aldehyde reductases from these species was estimated from a plot of difference index versus percent sequence difference for oxido-reductases of known sequence. From this plot, and using a mammal-chicken divergence time of 300 million years and a mammalian order split of 75 million years, the rate of evolution of aldehyde reductases was calculated to lie in the range 5.8 – 15.6% sequence difference per 100 million years. Comparison with rates of evolution of oligomeric dehydrogenases indicates that aldehyde reductases comprise the most rapidly evolving family of oxido-reductases. This is probably related to the monomericity of aldehyde reductases since there is a direct correlation between the number of subunits and the rate of evolution.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bencze, W.L., Schmid, K. (1957). Anal. Chem.29, 1192–1196
Black, J.A., Harkins, R.N. (1977). J. Theor. Biol.66, 281–295
Brown, H.M., Purves, W.K. (1976). J. Biol. Chem.251, 907–913
Champion, A.B., Soderberg, K.L., Wilson, A.C., Ambler, R.P. (1975). J. Mol. Evol.5, 291–305
Cornish-Bowden, A.J. (1977). J. Theor. Biol.65, 735–742
Cornish-Bowden, A.J. (1978). J. Theor. Biol.74, 155–161
Culp, H.W., McMahon, R.F. (1968). J. Biol. Chem.243, 848–852
Davidson, W.S., Walton, D.J., Flynn, T.G. (1978a). Comp. Biochem. Physiol.60B, 309–315
Davidson, W.S., Weihrauch, L., Flynn, T.G. (1978b). Biochem. Soc. Transac.6, 940–942
Dayhoff, M.O. (1978). Atlas of Protein Sequence and Structure Vol. 5, Suppl. 3, Washington: National Biomedical Research Foundation
Dedman, J.R., Gracy, R.W., Harris, B.G. (1974). Comp. Biochem. Physiol.49B, 715–731
Felsted, R.L., Gee, M., Bachur, N.R. (1974). J. Biol. Chem.249, 3672–3679
Flynn, T.G., Shires, J., Walton, D.J. (1975). J. Biol. Chem.250, 2933–2940
Harris, C.E., Teller, D.C. (1973). J. Theor. Biol.38, 347–362
Hers, H.G. (1960). Biochim. Biophys. Acta37, 120–126
Hirs, C.H.W. (1967). In: Methods in Enzymology, C.H.W. Hirs, ed., Vol. XI, pp 59–62, New York: Academic
Jornvall, H. (1977). Eur. J. Biochem.72, 443–452
Jornvall, H., Pietruszko, R. (1972). Eur. J. Biochem.25, 283–290
Kawalek, J.C., Gilbertson, J.R. (1976). Arch. Biochem. Biophys.173, 649–657
Kormann, A.W., Hurst, R.O., Flynn, T.G. (1972). Biochim. Biophys. Acta258, 40–50
Marchalonis, J.J., Weltman, J.K. (1971). Comp. Biochem. Physiol.38, 609–625
Metzger, H., Shapiro, M.B., Mosimann, J.E., Vinton, J.E. (1968). Nature219, 1166–1168
Prager, E.M., Wilson, A.C. (1971). J. Biol. Chem.246, 5978–5989
Riss, M.M., von Wartburg, J.P. (1973). Eur. J. Biochem.37, 69–77
Sheaff, C.M., Doughty, C.C. (1976). J. Biol. Chem.251, 2696–2702
Sneath, P.H.A., Sokal, R.R. (1973). In: Numerical Taxonomy, Sneath, P.H.A., Sokal, R.R. eds., p 230, San Francisco: Freeman
Tabakoff, B., Erwin, V.G. (1970). J. Biol. Chem.245, 3263–3268
Turner, A.J., Hick, P.E. (1976). Biochem. J.159, 819–822
Tulsiani, D.R.P., Touster, O. (1977). J. Biol. Chem.252, 2545–2550
Wermuth, G., Munch, J.D.B., von Wartburg, J.P. (1977). J. Biol. Chem.252, 3821–3828
Wilson, A.C., Carlson, S.S., White, T.J. (1977). Ann. Rev. Biochem.46, 573–639
Zuckerkandl, E. (1976). J. Mol. Evol. 7, 167–184
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davidson, W.S., Flynn, T.G. Compositional relatedness of aldehyde reductases from several species. J Mol Evol 14, 251–258 (1979). https://doi.org/10.1007/BF01732492
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01732492