Summary
All of ourEscherichia coli C mutants blocked in the first step of D-arabitol catabolism (D-arabitol dehydrogenase) became unable to grow in the presense of D-arabitol. We have shown that this sensitivity is eliminated by a defect in the second enzyme of the pathway (D-xylulokinase), leading to a pattern of toxicity and its relief which has not been previously reported. We have found a similar pattern of toxicity and its relief in the closely related ribitol pathway. The evolutionary significance of these findings is discussed.
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Scangos, G.A., Reiner, A.M. A unique pattern of toxic synthesis in pentitol catabolism: Implications for evolution. J Mol Evol 12, 189–195 (1979). https://doi.org/10.1007/BF01732338
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DOI: https://doi.org/10.1007/BF01732338