Summary
The fact that 64 base triplets code only about 20 essential amino acids implies a strong degeneracy of certain base doublets. It is shown that the set of degenerate base doublets and the set of non degenerate base doublets are highly structured. A mathematical formalism is introduced which allows a systematic description of the consequences of an exchange of bases in a doublet. By this formalism it is shown that the two mentioned sets have in fact the same structure.
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Danckwerts, H.J., Neubert, D. Symmetries of genetic code-doublets. J Mol Evol 5, 327–332 (1975). https://doi.org/10.1007/BF01732219
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DOI: https://doi.org/10.1007/BF01732219