Summary
The tissue and stage specificity of expression of five enzymes was examined by electrophoretic analysis of relative enzyme levels in extracts of 13 larval and adult tissues in 27 species of Hawaiian picture-wingedDrosophila. The developmentally regulated patterns of enzyme expression thus characterized were compared to a modal standard phenotype. About 30% of the pattern features analyzed differed significantly from the standard in one or more species. Many of these regulatory differences are essentially qualitative, with tissue specific differences in enzyme activity in excess of 100 fold for some species pairs. The adaptive significance of these pattern differences is unknown, but the results provide strong direct evidence for rapid evolution of new patterns of gene regulation in this group of organisms.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Abraham I, Doane WW (1978) Proc Nat Acad Sci USA 75:4446–4450
Ayala FJ (1976) Molecular evolution. Sinauer, Sunderland, Mass
Boubelik M, Lengerova A, Bailey DW, Matousek V (1975) Dev Biol 47:206–214
Carson HL, Kaneshiro KY (1976) Annu Rev Ecol Syst 7:311–345
Chovnick A, Gelbart W, McCarron M, Osmond B, Candido EPM, Baillie DL (1976) Genetics 84:232–255
David J (1977) Annee Biol 16:451–472
Dayhoff MO (1972) Atlas of protein sequence and structure. Vol 5, National Biomed Research Foundation, Silver Spring, Maryland.
Dickinson WJ (1970) Genetics 66:487–496
Dickinson WJ (1975) Dev Biol 42:131–140
Dickinson WJ (1978) J Exp Zool 206:333–342
Dickinson WJ (1980a) Science 207:995–997
Dickinson WJ (1980b) Devel Gen 1:229–240
Dickinson WJ, Carson HL (1979) Proc Nat Acad Sci USA 76:4559–4562
Dickinson WJ, Sullivan DT (1975) Gene-enzyme systems inDrosophila. Springer, Berlin, Heidelberg, New York
Ferris SD, Whitt GS (1979) J Mol Evol 12:267–317
Finnerty V, Duck P, Chovnick A (1970) Genet Res 15:351–355
Fisher SE, Whitt GS (1978) J Mol Evol 12:25–55
Gould SJ (1977) Ontogeny and phylogeny. Harvard Univ Press, Cambridge, Mass, p 405
King MC, Wilson AC (1975) Science 188:107–116
Klebe RJ (1975) Biochem Genet 13:805–812
Kolata GB (1975) Science 189:446–447
Lewontin RC (1974) The genetic basis of evolutionary change. Columbia University Press, New York
Lewontin RC, Hubby JL (1966) Genetics 54:595–609
Lusis AJ, Paigen K (1975) Cell 6:371–378
Markert CL, Shaklee JB, Whitt GS (1975) Science 189:102–114
Nevo E (1978) Theoret Popul Biol 13:121–177
Paigen K (1961) Proc Nat Acad Sci USA 47:1641–1649
Paigen, K (1971) The genetics of enzyme realization. In: Rechcigl M (ed), Enzyme synthesis and degradation in mammalian systems. University Park Press, Baltimore, p 1
Paigen K (1979) Genetic factors in developmental regulation. In: Scandalios JG (ed) Physiological genetics. Academic Press, New York, p 1
Paigen K, Meisler M, Felton J, Chapman V (1976) Cell 9:533–539
Paigen K, Swank RT, Tomino S, Ganschow RE (1975) J Cell Physiol 85:379–392
Phillip DP, Childers WF, Whitt GS (1979) J Exp Zool 210:473–488
Powell JR (1979) Genetics 92:613–622
Powell JR, Lichtenfels TM (1979) Genetics 92:603–612
Rosbash M, Campos MS, Gummerson KS (1975) Nature 258:682–686
Schwartz D (1962) Genetics 47:1609–1615
Schwartz D (1976) Proc Nat Acad Sci USA 73:582–584
Shaklee JB, Kepes KL, Whitt GS (1973) J Exp Zool 185:217–240
Shows TB, Massara EJ, Ruddle FH (1969) Biochem Genet 3:525–536
Snyder LRG (1978) Genetics 89:531–550
Thompson JN, Ashburner M, Woodruff RC (1977) Nature 270:363
Wheeler MR, Clayton FE (1965) Dros Inf Serv 40:98
Whitt GS, Phillip DP, Childers WF (1977) Differentiation 9:97–109
Wilson AC (1976) Gene regulation in evolution. In: Ayala FJ (ed), Molecular evolution. Sinauer, Sunderland, Mass, p 225
Wilson AC, Carlson SS, White TJ (1977) Annu Rev Biochem 46:573–639
Zuckerkandl E (1963) Perspectives in molecular anthropology. In: Washburn S (ed), Classification and human evolution. Aldine Publishing, Chicago, p 243
Zuckerkandl E (1978) J Mol Evol 12:57–89
Zuckerkandl E, Pauling L (1965) In: Bryson V, Vogel HJ (eds), Evolving genes and proteins. Academic Press, New York, p 97
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dickinson, W.J. Evolution of patterns of gene expression in Hawaiian picture-wingedDrosophila . J Mol Evol 16, 73–94 (1980). https://doi.org/10.1007/BF01731579
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01731579