Summary
A suppression and delay in reaching the peak of primary humoral response in mice was noted when relatively large dosage of methylmercury was administered in a short time period, suggesting the interference with the initial multiplications of antibody producing cells. On the other hand, sub chronic administration of low levels of methylmercury in diet (0.5 and 5 ppm) caused no definite suppression on either primary or secondary responses, though they tended to be depressed.
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CUNNINGHAM, A. J. and SZENBERG, A.: Immunology14, 599 (1968)
DOI, R.: Jap. J. Hyg.30, 47 (1975)
PISKEJO, G.: Hereditas64, 142 (1970)
HOSONO, O., TANZAWA, K., HASEGAWA, Y. and UKITA, T.: J. Hyg. Chem. (Japan)12, 90 (1966)
KLEIN, R., HERMAN, S. P., BRUBAKER, P. E. and LUCIER, G. W.: Arch. Path.93, 408 (1972)
KOLLER, L. D.: Am. J. Vet. Res.,34, 1457 (1973)
MAKINODAN, T. and PETERSEN, W.: Develop. Biol.14, 96 (1966)
MANSOUR, M. M., DYER, N. C., HOFFMAN, L. H., SCHULENT, A. R. and BRILL, A. B.: Environ. Res.6, 479 (1973)
NISHIMA, T., IKEDA, S., TADA, T., YAGYU, H. and NAGASAKI, M.: Ann. Rep. Tokyo. Metr. Res. Lab. Pub. Health,25, 94 (1974)
RAMERL, C. and MAGNUSSON, J.: Hereditas61, 208 (1968)
SAKAI, K.: Kumamoto Med. J.25, 94 (1972)
SUZUKI, T., MIYAMA, T. and KATSUNUMA, H.: Bull. Environ. Contam. Toxic.5, 502 (1971)
TAKEUCHI, T.: Read before the International Conference on Environmental Mercury Contamination. Ann Arbor, Mich., 1970
THRASHER, J. D. and ADAMS, J. F.: Environ. Res.5, 443 (1972)
UMEDA, M., SAITO, K., HIROSE, K. and SAITO, M.: Jap. J. Exp. Med.39, 47 (1969)
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Ohi, G., Fukuda, M., Seto, H. et al. Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations. Bull. Environ. Contam. Toxicol. 15, 175–180 (1976). https://doi.org/10.1007/BF01685157
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DOI: https://doi.org/10.1007/BF01685157