Summary
Mycoplasma pneumoniae attaches to a variety of surfaces. Adherence to inert surfaces such as glass requires an intact energy metabolism. Interaction with sheep erythrocytes occurs via a binding protein on the mycoplasma surface. The protein reacts with a receptor containing sialic acid. Adherence to other erythrocytes may involve different mechanisms. Different results have been reported on interaction with tissue cells. The various mechanisms probably cooperate and thereby facilitate the colonization of the human respiratory tract.
Zusammenfassung
Mycoplasma pneumoniae vermag sich an verschiedenartige Oberflächen anzuheften. Adhärenz an Glas und ähnliche inerte Materialien verlangt einen intakten Energiestoffwechsel. Die Bindung an Schaferythrozyten wird durch ein Oberflächenprotein der Mycoplasma-Membran vermittelt, das mit einem Neuraminsäurehaltigen Rezeptor reagiert. Bei der Anheftung an andere Erythrozyten scheinen noch weitere Mechanismen beteiligt zu sein. Für die Interaktion mit Gewebezellen werden teilweise unterschiedliche Ergebnisse berichtet. Das Zusammenwirken der verschiedenen Mechanismen ermöglicht die erfolgreiche Kolonisierung des menschlichen Respirationstraktes.
Article PDF
Avoid common mistakes on your manuscript.
Literature
Tully, J. G., Whitcomb, R. F. (eds.): The mycoplasmas, Vol. II. Academic Press, New York 1979.
Stanbridge, E. J., Weiss, R. C. Mycoplasma capping on lymphocytes. Nature 276 (1978) 583–587.
Freundt, E. A., Edward, D. G. ff. Classification and taxonomy. In:Barile, M. F., Razin, S. (eds.): The mycoplasmas. Vol. I, Academic Press, New York 1979, pp. 1–41.
Bredt, W. Motility of mycoplasmas. Ann. N. Y. Acad. Sci. 225 (1973) 247–250.
Biberfeld, G., Biberfeld, P. Ultrastructural features ofMycoplasma pneumoniae. J. Bacteriol. 102 (1970) 855–861.
Bredt, W., Feldner, J., Kahane, I. Attachment of mycoplasmas to inert surfaces. In: Adhesion and microorganism pathogenicity. Ciba Foundation Symposium 80. Pitman Medical, Tunbridge Wells 1981, pp. 98–113.
Bredt, W., Feldner, J., Kahane, I. Adherence of mycoplasmas to cells and inert surfaces: Phenomena, experimental models and possible mechanisms. Isr. J. Med. Sci. 17 (1981) 586–588.
Razin, S., Kahane, I., Banai, M., Bredt, W. Adhesion of mycoplasmas to eukaryotic cells. In: Adhesion and microorganism pathogenicity. Ciba Foundation Symposium 80. Pitman Medical, Tunbridge Wells 1981, pp. 3–16.
Collier, A. M. Mycoplasmas in organ culture. In:Tully, J. G., Whitcomb, R. F. (eds.): The mycoplasmas. Vol. II, Academic Press, New York 1979, pp. 475–493.
Feldner, J., Bredt, W., Razin, S. Possible role of ATP and cyclic AMP in glass attachment ofMycoplasma pneumoniae. FEMS Microbiol. Letters 11 (1981) 253–256.
Göbel, U., Speth, V., Bredt, W. Filamentous structures in adherentMycoplasma pneumoniae cells treated with non-ionic detergents. J. Cell Biol. 91 (1981) 537–543.
Gorski, F., Bredt, W. Studies on the adherence mechanism ofMycoplasma pneumoniae. FEMS Microbiol. Letters 1 (1977) 265–268.
Banani, M., Razin, S., Bredt, W., Kahane, I. Isolation of binding sites to glycophorin fromMycoplasma pneumoniae membranes. Infect. Immun. 30 (1980) 628–634.
Hansen, E. J., Wilson, R. M., Clyde, W. A. Jr., Baseman, J. B. Characterization of hemadsorption-negative mutants ofMycoplasma pneumoniae. Infect. Immun. 32 (1981) 127–136.
Gabridge, M. G., Taylor-Robinson, D. Interaction ofMycoplasma pneumoniae with human lung fibroblasts: Role of receptor sites. Infect. Immun. 25 (1979) 455–459.
Erb. P., Bredt, W. Interaction ofMycoplasma pneumoniae with alveolar macrophages: Viability of adherent and ingested mycoplasmas. Infect. Immun. 25 (1979) 11–15.
Brunner, H. Mycoplasma pneumoniae infections. Isr. J. Med. Sci. 17 (1981) 515–523.
Gingell, D., Vince, S. Long range forces and adhesion. An analysis of cell-substratum studies. In:Curtis, A. S. G., Pitts, J. D. (eds.): Cell adhesion and motility. Cambridge University Press, Cambridge 1980, pp. 1–37.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bredt, W., Feldner, J. & Klaus, B. Adherence of mycoplasmas: Phenomena and possible role in the pathogenesis of disease. Infection 10, 199–202 (1982). https://doi.org/10.1007/BF01640779
Issue Date:
DOI: https://doi.org/10.1007/BF01640779