Summary
CP-61,405 (C26H29N2O7Na) is a novel polycyclic pyrrolether antibiotic produced by a new species,Streptomyces routienii Huang sp. nov. (ATCC 39446). Recovery, fractionation and purification were achieved using standard procedures. The crystalline form includes the CP-61,405 sodium salt, m.p. 334–335°C, [α] 25°CD +315°C (c=1, chloroform). The structure is shown below. CP-61,405 was co-produced with the polycyclic ether antibiotics salinomycin and epi-17-deoxy-(0–8)-salinomycin. It exhibited activity in vitro against gram-positive and anaerobic bacteria, efficacy against poultry coccidia and stimulation in vitro of propionic acid production.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Chaney, M.O., P.V. Demarco, N.D. Jones and J.J. Occolowitz. 1974. The structure of A-23187, a divalent cation ionophore. J. Am. Chem. Soc. 96: 1932–1933.
Chappel, L.R., H.L. Howes and J.E. Lynch. 1974. The site of action of a broad-spectrum aryltriazine anticoccidial, CP-25,415. J. Parasitol. 60: 415–420.
David, L. and A. Kergomard. 1982. Production by controlled biosynthesis of a novel ionophore antibiotic, cezomycin (demethylamino A-23187). J. Antibiot. 35: 1409–1411.
Huang, L.H. 1980.Actinomadura maera sp. nov., the producer of antibiotics CP-47,433 and CP-47,434. Int. J. Syst. Bacteriol. 30: 565–568.
Kellog, D.W. 1969. Analysis of rumen fluid volatile fatty acids by chromatography with porapak Q.S.. J. Dairy Sci. 52: 1690–1692.
Kinashi, H., N. Otake, H. Yenehara, S. Sato and V. Saito. 1973. The structure of salinomycin, a new member of the polyether antibioties. Tetrahedron Lett. 49: 4955–4958.
Reed, P.W. 1982. Biochemical and biological effects of carboxylic acid ionophores. In: Polyether Antibiotics: Naturally Oceurring Acid lonophores, Vol. I: Biology Westley, J.W., ed.), pp. 369–396, Marcel Dekker, Inc., New York.
Shirling, E.B. and D. Gottlieb. 1966. Methods for characterization ofStreptomyces species. Int. J. Syst. Bacteriol. 16: 313–340.
Waksman, S.A. 1961. The Actinomycetes, Vol. II. The Williams and Wilkins Co., Baltimore, MD.
Westley, J.W., J.F. Blount, R.H. Evans, Jr. and C.-M. Liu. 1977. C-17 epimers of deoxy-(0–8)-salinomycin fromStreptomyces albus (ATCC 21838). J. Antibiot. 30: 610–612.
Westley, J.W., C.M. Liu, J.F. Blount, L.H. Sello, N. Troupe and P.A. Miller. 1983. Isolation and characterization of a novel polyether antibiotic of the pyrrolether class, antibiotic X-14885A. J. Antibiot. 366: 1275–1278.
Yaginuma, S., A. Masashi, N. Muto, K. Kinoshita and K. Mizuno. 1987. A novel polyether antibiotic AC 7230 (3-hydroxycezomycin or its stereoisomer). J. Antibiot. 40: 239–241.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cullen, W.P., Celmer, W.D., Chappel, L.R. et al. CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.. Journal of Industrial Microbiology 2, 349–357 (1988). https://doi.org/10.1007/BF01569573
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01569573