Summary
A pituitary adenoma in a 67-year-old man was characterized by abundant mitochondria and identified as an oncocytoma, which clinically and histologically appeared as a chromophobe adenoma. In addition to the numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria were also present. Compared with other pituitary oncocytomas reported in the literature, abnormally structured mitochondria appear rare among the mitochondrial population of pituitary oncocytomas.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Gjerris, A., Lindholm, J., Riishede, J., Pituitary oncocytic tumor with Cushing's disease. Cancer42 (1978), 1818–1822.
Hachmeister, U., Ultrastructural aspects of anterior pituitary tumors. In: Modern aspects of neurosurgery (Kuhlendahl, H., Brock, M., Le Vay, D., Weston, T. J., eds.), Vol. 4, pp. 108–115. Proceedings of the German Society of Neurosurgery. Amsterdam: Excerpta Medica. 1973.
Heffner, R. R., Barron, S. A., The early effects of ischemia upon skeletal muscle mitochondria. J. Neurol. Sci.38 (1978), 295–315.
Horvath, E., Kovacs, K., Ultrastructural classification of pituitary adenomas. J. Canad. Sci. neurol.3 (1976), 9–21.
Karpati, G., Carpenter, S., Melmed, C., Eisen, A. A., Experimental ischemic myopathy. J. neurol. Sci.23 (1974), 129–161.
Kovacs, K., Horvath, E., Pituitary “chromophobe” adenoma composed of oncocytes. A light and electron microscopic study. Arch. Path.95 (1973), 235–239.
— —, Bilbao, J. M., Oncocytes in the anterior lobe of the human pituitary gland. A light and electron microscopic study. Acta neuropath.27 (1974), 43–54.
Landolt, A. M., Ultrastructure of human sella tumours. Correlation of clinical findings and morphology. Acta neurochir. (Wien), Suppl.22 (1975), 1–167.
—, Oswald, U. W., Histology and ultrastructure of an oncocytic adenoma of the human pituitary. Cancer31 (1973), 1099–1105.
Paiz, C., Hennigar, G. R., Electron microscopy and histochemical correlation of human anterior pituitary cells. Amer. J. Path.59 (1970), 43–74.
Roy, S., Ultrastructure of oncocytic adenoma of the human pituitary gland. Acta neuropath. (Berl.)41 (1978), 169–171.
Saeger, W., Die Hypophysentumoren. Pituitary tumors. In: Progress in Pathology (Büngeler, W., Eder, M., Lennert, K., Peters, G., Sandritter, W., Seifert, G., eds.), Vol. 107. Stuttgart-New York: G. Fischer. 1977.
Author information
Authors and Affiliations
Additional information
This paper is dedicated to Hans Orthner, M.D., on the occasion of his 65th birthday.
Rights and permissions
About this article
Cite this article
Goebel, H.H., Schulz, F. & Rama, B. Ultrastructurally abnormal mitochondria in the pituitary oncocytoma. Acta neurochir 51, 195–201 (1980). https://doi.org/10.1007/BF01406745
Issue Date:
DOI: https://doi.org/10.1007/BF01406745