Summary
We report 137 recurrent supratentorial astrocytomas. The primary tumours diagnosed on the basis of a grading system with three stages were 72 astrocytomas I and 65 astrocytomas II. In the first group 14% of the recurrences were not changed, 55.5% became astrocytomas II, and 30.5% became glioblastomas. In the second group 55.4% were unchanged, and 44.6% became glioblastomas. The postoperative intervals until reintervention or death were statistically examined. It seems that the recurrence time chiefly depends on the nature of the primary tumour. The transformation of an astrocytoma I to a glioblastoma takes longer than the transformation of an astrocytoma II into a glioblastoma. In about two thirds of all astrocytomas an increase of malignancy is to be expected. From the histological picture it is not possible in an individual case to predict the likelihood or speed of malignant change. With regard to the effect of irradiation the authors conclude that radiotherapy most probably does not produce malignancy.
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References
Alwasiak, J., Microscopic appearance of recidivant and incompletely removed supratentorial gliomas (Polish). Neuropat. pol.8 (1970), 37–78.
Bailey, P., Sosman, M., Dessel, A. van, Roentgen therapy of gliomas of the brain. Amer. J. Roentgenol.19 (1928), 203–264.
Cornil, L., Paillas, J. E., Badier, M., Sur les récidives des gliomes bénins. Rev. Neurol.84 (1951), 494–499.
Finkemeyer, H., Krämer, W., Pfingst, E., Tzonos, T., Malignität und Rezidiv bei den hirneigenen Tumoren. Acta Neurochir. (Wien)13 (1965), 310–312.
Globus, J. H., Die Umwandlung gutartiger Gliome in bösartige Spongioblastome. Z. Neurol. (Berl.)134 (1931), 325.
Gluszcz, A., Dysplastic features in glial tumours. Proc. 6th. Int. Congr. Neuropath., Paris 1970, pp. 512–529. Masson et Cie. 1970.
—, Grouping of supratentorial gliomas according to their dominant biomorphological features. Acta neuropath. (Berl.)22 (1972), 110–126.
—, Giernat, L., Habryka, K., Alwasiak, J., Lach, B., Papierz, W., Rosenthal fibers, birefringent gliofibrillary changes and intracellular conglomerates in tissue cultures of gliomas. Acta neuropath, (Berl.)17 (1971), 54–67.
Gullotta, F., Kersting, G., Wüllenweber, R., Recurrences of gliomas. A comparative clinical and morphological study with a note on the histological grading of astrocytomas. Proc. Germ. Soc. Neurosurg. Düsseldorf 1971. Excerpta Med. Amsterdam3 (1973), 116–121.
Kernohan, J. W., Mabon, R. F., Svien, H. J., Adson, A. W., Simplified classification of gliomas. Proc. Mayo Clin.24 (1949), 71–75.
Khominsky, B. S., itO novykh napravleniyakh v traktovke i klassifikatsii glialnykh opukholei (Russ.). Arkh. Pat. (Mosk.)19 (1957), 3–17.
—, Stepeni zlokachestvennosti i ikh otrazhenie v sovremennykh klassifikatsiyakh opukholei nervoi sistemy (Russ.). Vopr. Neirokhir.27 (1963), 1–7.
Kuhlendahl, H., Miltz, H., Wüllenweber, R., Die Astrozytome des Großhirns. Untersuchungen zur Gruppierung und Prognose. Acta Neurochir. (Wien)29 (1973), 151–162.
Løken, A. G., Histological grouping of brain tumors in a 10 years material. Acta path, microbiol. scand. Suppl.93 (1952), 135–147.
Molitor, M., Histologische Untersuchungen zur Frage der Malignitätszunahme bei Gliomrezidiven. Inaug. Diss. Univ. Köln 1966.
Müller, W., Schröder, R., Zur Diagnostik der Gliome. Acta Neurochir. (Wien)11 (1968), 30–36.
Ostertag, B., Anatomie und Pathologie der raumfordernden Prozesse des Schädelinnenraumes. In: Neue Deutsche Chirurgie, Bd. 50/III. Stuttgart: F. Enke. 1941.
Ringertz, N., “Grading” of gliomas. Acta path, microbiol. scand.27 (1950), 51–64.
Sachs, L., Statistische Auswertungsmethoden, 3. Aufl., p. 185. Berlin-Heidelberg-New York: Springer. 1972.
Scheinker, J., Über die Umwandlung gutartiger Hirngliome (Astrocytome) m bösartige Glioblastome. Dtsdi. Z. Nervenheilk.145 (1938), 54–69.
Scherer, H. J., Les astrocytomes cérébraux et leur rapport avec les gliobastomes. Verh. 3. Intern. Neurol. Kongr. 1939, p. 475.
Schiffer, D., Fabiani, A., Patologia dei tumori cerebrali. Roma: “Il Pensiero Scientifico” Ed. 1970.
Schlote, W., Rosenthalsche Fasern und Spongioblasten im Zentralnervensystem. Beitr. path. Anat.133 (1966), 225–248, 461–480.
Schröder, R., Bonis, G., Müller, W., Vorreith, M., Statistische Beiträge zum Grading der Gliome. I. Glioblastom — Anamnese. Acta Neurochir. (Wien)18 (1968 a), 43–56.
— — — —, Statistische Beiträge zum Grading der Gliome. II. Glioblastom — Katamnese und Erkrankungsalter. Acta Neurochir. (Wien)18 (1968 b), 186–200.
— — — —, Statistische Beiträge zum Grading der Gliome. III. Astrocytome und Oligodendrogliome. Acta Neurochir. (Wien)23 (1970), 1–29.
Stender, H. St., Rundtischgespräch über die Probleme der Strahlenbehandlung der Hirngeschwülste. In: Diagnostische und therapeutische Fragen bei Hirngeschwülsten, pp. 138–153. Stuttgart: G. Thieme. 1968.
Vázquez, J., Beiträge zur Pathologie der Gliomrezidive. Zbl. Neurochir.27 (1966), 1–19.
Vorreith, M., Fuchsová, M., Fusek, I., Šourek, K., Fryc, O., Hodnocení biologických vlastností a progózy gliomů (Czech.). Čs. Neurol.26 (1963), 311–316.
Walter, W., Müller, W., Histologische Veränderungen an röntgenbestrahlten Gliomen. Zbl. Neurochir.19 (1959), 79–90.
—, Schettler, G., Müller, W., Klinik und Operabilität der rasch wachsenden Großhirngliome. Dtsch. Z. Nervenheilk.196 (1969), 1–19.
Tooth, H. H., Some observations on the growth and survival period of intracranial tumors. Brain35 (1912), 61–108.
Zülch, K.-J., Biologie und Pathologie der Hirngeschwülste. In: Handbuch Neurochirurgie, Bd. III, pp. 1–702. Berlin-Göttingen-Heidelberg: Springer. 1956.
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The authors wish to express their gratitude to the founder and organizer of the Institute of Neurosurgery in Budapest, Prof. Dr. L. Zoltán (†), for his promotion of these investigations.
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Müller, W., Áfra, D. & Schröder, R. Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with astrocytomas. Acta neurochir 37, 75–91 (1977). https://doi.org/10.1007/BF01401927
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DOI: https://doi.org/10.1007/BF01401927