Summary
Gangliosides isolated from the brain of ten-day-old Swiss albino mice were purified by thin layer chromatography, and the resulting purified gangliosides were tested for their ability to inhibit hemagglutination by Eastern Equine Encephalitis virus. The trisialoganglioside and the more rapidly migrating of the two disialogangliosides were found to inhibit hemagglutination. It is postulated that the neuraminic acid moiety of these gangliosides is necessary for the hemagglutination inhibition property.
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The data used in this paper were taken from the dissertation of M.T.Z. submitted to the Facultad de Ciencias Químicas on partial fulfillment of the requirement of the degree of Doctor in Biochemistry.
Ex-recipient of a scholarship in Virology.
Member of the Research Career of Consejo Nacional de Investigaciones Científicas y Técnicas de la R.A. (CONICET).
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Zapata, M.T., Paglini, S. Mouse brain gangliosides. Their property of inhibiting EEE virus hemagglutination. Archiv f Virusforschung 43, 184–190 (1973). https://doi.org/10.1007/BF01250413
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DOI: https://doi.org/10.1007/BF01250413