Abstract
The effects of fumonisin on development of Syrian hamster fetuses were studied using fumonisin B1 and B2 extracted fromFusarium moniliforme corn-culture and purified fumonisin B1. A significant increase in litters with fetal deaths occurred with the high doses of purified (18 mg FB1/kg) and culture-extracted (18 mg FB1 plus 4.5 mg FB2) fumonisin. It is concluded that prenatal exposure to fumonisin on days 8 and 9 of gestation is detrimental to fetal hamster survivability but does not induce clinical maternal intoxication at these doses. Equivalent doses of fumonisin B1, whether from culture-extract or pure solution produced similar results.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Marasas WFO, Kellerman TS, Gelderblom WCA, Coetzer JAW, Thiel PG, Van der Lugt JJ. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated fromFusarium moniliforme. Onderstepoort J Vet Res 1988; 55: 197–203.
Kellerman TS, Marasas WFO, Thiel PG, Gelderblom WCA, Cawood M, Coetzer JAW. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort J Vet Res 1990; 57: 269–75.
Gelderblom WCA, Kriek NPJ, Marasas WFO, Thiel PG. Toxicity and carcinogenicity of theFusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 1991; 7: 1247–51.
Harrison LR, Colvin BM, Greene JT, Newman LE, Cole Jr, RJ. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite ofFusarium moniliforme. J Vet Diagn Invest 1990; 2: 217–21.
Casteel SW, Turk JR, Cowart RP, Rottinghaus GE. Chronic toxicity of fumonisin in weanling pigs. J Vet Diagn Invest 1993; 5: 413–17.
Casteel SW, Turk JR, Rottinghaus GE. Chronic effects of dietary fumonisin on the heart and pulmonary vasculature of swine. Fundam Appl Toxicol (accepted for publication).
Javed T, Richard JL, Bennett GA, Dombrink-Kurtzman MA, Bunte RM, Koelkebeck KW, Cote LM, Leeper RW, Buck WB. Embryopathic and embryocidal effects of purified fumonisin B1 orFusarium proliferatum culture material extract on chicken embryos. Mycopathologia 1993; 123: 185–93.
Floss JL, Casteel SW, Johnson GC, Rottinghaus GE, Krause GF. Developmental toxicity in Hamsters of an aqueous extract ofFusarium moniliforme culture material containing known quantities of fumonisin B1. Vet Hum Toxicol 1994; 36: 5–10.
Weibking TS, Ledoux DR, Bermudez AJ, Turk JR, Rottinghaus GE, Wang E, Merrill AH. Effects of feedingFusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. Poultry Sci 1993; 72.
Wilson TM, Ross PF, Rice LG, Osweiler GD, Nelson HA, Owens DL, Plattner RD, Reggiardo C, Noon TH, Pickrell JW. Fumonisin B1 levels associated with an epizootic of equine leukoencephalomalacia. J Vet Diagn Invest 1990; 2: 213–16.
Boyer CC. Embryology. In: Hoffman RA, Robinson PF, Magalhaes H, eds. The Golden Hamster: Its biology and use in medical research. Ames: Iowa State University Press, 1968: 73–89.
Manson JM, Kang YJ. Test methods for assessing female reproductive and developmental toxicology. In: Hayes AW, ed. Principles and methods of toxicology, 2nd ed. New York: Raven Press, 1989: 311–59.
Mitruka BM, Rawnsley HM. Clinical biochemical and hematological reference values in normal experimental animals and normal humans, 2nd ed. New York: Masson, 1981: 167–71.
Voss KA, Norred WP, Plattner RD, Bacon CW. Hepatotoxicity and renal toxicity of corn samples associated with field cases of equine leukoencephalomalacia. Food Chem Toxicol 1989; 27: 89–96.
Osweiler GD, Ross PF, Wilson TM, Nelson PE, Witte ST, Carson TL, Rice LG, Nelson HA. Characterization of an epizootic of pulmonary edema in swine associated with fumonisin in corn screenings. J Vet Diagn Invest 1992; 4: 53–59.
Black DL, Marks TA. Role of maternal toxicity in assessing developmental toxicity in animals: A discussion. Regul Toxicol Pharmacol 1992; 16: 189–201.
Shenefelt RE. Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment. Teratology 1972; 5: 103–18.
Wang W, Norred WP, Bacon CW, Riley RT, Merrill Jr, AH. Inhibition of sphingolipid biosynthesis by fumonisins, Implications for diseases associated withFusarium moniliforme. J Biol Chem 1991; 266: 14486–90.
Riley RT, An NH, Showker JL, Yoo HS, Norred WP, Chamberlain WJ, Wang E, Merrill AH, Motelin G, Beasley VR, Haschek WM. Alteration of tissue and serum sphingamine to sphingosine ratio: An early biomarker of exposure to fumonisincontaining feeds in pigs. Toxicol Appl Pharmacol 1993; 118: 105–12.
Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 1989; 243: 500–7.
Manson JM, Wise CD. Teratogens. In: Amdur MO, Doull J, Klaassen CD, eds. Casarett and Doull's toxicology: The basic science of poisons, 4th ed. New York: Pergamon Press, 1991: 226–54.
Gelderblom WCA, Marasas WFO, Vleggaar R, Thiel PG, Cawood ME. Fumonisins: Isolation, chemical characterization and biological effects. Mycopathologia 1992; 117: 11–16.
Szabo KT. Congenital malformations in laboratory and farm animals. San Diego: Academic Press, 1989: pp.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Floss, J.L., Casteel, S.W., Johnson, G.C. et al. Developmental toxicity of fumonisin in Syrian hamsters. Mycopathologia 128, 33–38 (1994). https://doi.org/10.1007/BF01104276
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01104276