Abstract
Levonorgestrel dissolves only slightly in water. Attempts were made to increase the solubility properties of this drug by complexing with cyclodextrins. The products were investigated with a dissolution tester and a Sartorius resorption model. X-ray and NMR spectra of the inclusion complexes were analysed.
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References
USP XXIII and NF XVIII. US Pharmacopeial Convention, Inc., 1994
Szejtli, J., Cyclodextrin Technology, Kluwer Academic Publishers, Dordrecht, 1988
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Aigner, Z., Dombi, G. & Kata, M. Increasing the solubility characteristics of D-norgestrel with cyclodextrins. J Incl Phenom Macrocycl Chem 25, 145–148 (1996). https://doi.org/10.1007/BF01041556
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DOI: https://doi.org/10.1007/BF01041556