Abstract
This article reviews recent advances in the understanding of mast cell-nervous system interactions. It is drawn largely from work published within the last ten years, and discusses the anatomical and biochemical evidence of a functional connection between mast cells and the nervous system, and the implications that such a relationship may have for normal and abnormal physiological functioning. Mast cells are found at varying levels of association with the nervous system; in CNS parenchyma (mainly thalamus), in connective tissue coverings (e.g. meninges, endonerium), and in close apposition to peripheral nerve endings in a variety of tissues. There is, as yet, no clearly defined role for mast cells in nervous system function, or vice-versa, and it seems most likely that their interactions fulfil mutually modulatory roles. By extension, pathological situations where one of the partners in this relationship is overly stimulated may lead to a dysregulation of the other, and contribute to disease symptomatology.
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Abbreviations
- ACh:
-
acetylcholine
- BMMC:
-
bone marrow-derived mast cells
- CGRP:
-
calcitonin gene-related peptide
- EAE:
-
experimental allergic encephalomyelitis
- EAN:
-
experimental allergic neuritis
- 5-HT:
-
serotonin
- IgE:
-
immunoglobulin E
- IL-3:
-
interleukin-3
- MS:
-
multiple sclerosis
- NA:
-
noradrenaline
- NF:
-
neurofibromatosis
- NGF:
-
nerve growth factor
- VIP:
-
Vasoactive intestinal polypeptide
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Special issue dedicated to Dr. Alan N. Davison.
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Johnson, D., Krenger, W. Interactions of mast cells with the nervous system —Recent advances. Neurochem Res 17, 939–951 (1992). https://doi.org/10.1007/BF00993271
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DOI: https://doi.org/10.1007/BF00993271