Abstract
By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.
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Sorgato, M.C., Moran, O., De Pinto, V. et al. Further investigation on the high-conductance ion channel of the inner membrane of mitochondria. J Bioenerg Biomembr 21, 485–496 (1989). https://doi.org/10.1007/BF00762520
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DOI: https://doi.org/10.1007/BF00762520