Summary and Conclusion
The immediate and chronic effects of exercise on hematocrit, hemoglobin and red cell fragility have been studied in splenectomized and sham-operated rats. The training program consisted of an initial 35 minute swim in water at 35 ° C. The duration of the swim was increased 5 minutes per day until reaching 60 minutes and continued for 42 days. Splenectomization had no effect on organ weights, hemoglobin content, hematocrit or red cell fragility. The adrenals and heart ventricles of the trained animals were heavier, whereas their livers and spleens were significantly smaller. Training had no effect on per cent hemoglobin or hematocrit, however, red cells from trained animals were less resistant to osmotic pressure. No differences in hemoglobin or hematocrits were found between splenectomized and sham-operated animals immediately after exercise. It is concluded that in the rat the spleen does not make a significant contribution to these components of blood during exercise.
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Gollnick, P.D., Struck, P.J., Soule, R.G. et al. Effect of exercise and training on the blood of normal and splenectomized rats. Int. Z. Angew. Physiol. Einschl. Arbeitsphysiol. 21, 169–178 (1965). https://doi.org/10.1007/BF00696788
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DOI: https://doi.org/10.1007/BF00696788