Summary
The fine structure and reproductive mechanisms of Toxoplasma gondii are described in a case of toxoplasma encephalitis. Replication was observed in glial cells by an internal budding process: endodyogeny. Distinctive ultrastructural features associated with host cell penetration, and encystation are described. Electron microscopic features previously reported in tissue culture and in experimentally produced infections with T. gondii are confirmed in the human brain tissue.
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Supported by grant NS 09053 and NS 14162 from the National Institute of Neurological and Communicative Disorders and Stroke.
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Powell, H.C., Gibbs, C.J., Lorenzo, A.M. et al. Toxoplasmosis of the central nervous system in the adult. Electron microscopic observations. Acta Neuropathol 41, 211–216 (1978). https://doi.org/10.1007/BF00690438
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DOI: https://doi.org/10.1007/BF00690438