Summary
A new animal model for the study of diabetic neuropathy is presented. The homozygote (db/db) of the mouse strain C57BL/Ks shows severe diabetes with longstanding hyperglycemia. Electrophysiological studies showed severely decreased motor nerve conduction velocity. Morphometric examination of sensory and motor nerves at different levels revealed absence of large myelinated fibers, with morphological features indicative of axonal atrophy.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Ballin, R. H. M., Thomas, P. K.: Hypertrophic changes in diabetic neuropathy. Acta neuropath. (Berl.)11, 93–102 (1968)
Chopra, J. S., Hurwitz, L. J., Montgomery, D. A. D.: The pathogenesis of sural nerve changes in diabetes mellitus. Brain92, 391–418 (1969)
Chopra, J. S., Faunin, T.: Pathology of diabetic neuropathy. J. Pathol.104, 175–184 (1971)
Coleman, D. L., Hummel, K. P.: Studies with the mutation diabetes in the mouse. Diabetologia3, 238–248 (1967)
Dolman, C. L.: The morbid anatomy of diabetic neuropathy. Neurology (Minneap.)13, 135–142 (1963)
Downie A. W., Newell, D. J.: Sensory nerve conduction in patients with diabetes mellitus and controls. Neurology (Minneap.)11, 876–882 (1961)
Eliasson, S. G.: Nerve conduction changes in experimental diabetes. J. Clin. Invest.43, 2353–2358 (1964)
Fry, J. K., Hardwick, C., Scott, G. W.: Diabetic neuropathy: A survey and follow-up of 66 cases. Guy's Hosp. Rep.,111, 113 (1962)
Greenbaum, D., Richardson, P. C., Salmon, M. V., Ulrich, H.: Pathological observations on six cases of diabetic neuropathy. Brain87, 201–214 (1964)
Gilliott, R. W., Willison, R. G.: Peripheral nerve conduction in diabetic neuropathy. J. Neurol. Neurosurg. Psych.25, 11–18 (1962)
Hildebrand, J., Joffroy, A., Grott, G., Coers, C.: Neuromuscular changes with alloxan hyperglycemia. Electrophysiological, biochemical and histological study in rats. Arch. Neurol.18, 638–641 (1968)
Hummel, K. P., Dickie, M. M., Coleman, D. L.: Diabetes, a new mutation in the mouse. Science153, 1127–1128 (1966)
Jakobsen, J.: Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves. Diabetologia12, 539–546 (1976)
Lawrence, D. G., Locke, S.: Motor nerve conduction velocity in diabetes. Arch. Neurol.5, 483–489 (1961)
Like, A. A., Chick, W. L.: Studies in the diabetic mutant mouse: I. Lightmicroscopy and radioautography of pancreatic islets. Diabetologia6, 207–215 (1970)
Miyoshi, T., Goto, I.: Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes. Electroenceph. Clin. Neurophysiol.35, 125–131 (1973)
Mulder, D. W., Lambert, E. H., Bastron, J. A., Spraque, R. G.: The neuropathies associated with diabetes mellitus: A clinical and electromyographic study of 103 unselected diabetic patients. Neurology (Minneap.)11, 275–284 (1961)
Olsson, Y., Säve-Söderbergh, J., Sourander, P., Angervall, L.: A pathoanatomical study of the central and peripheral nervous system in diabetes of early onset and long duration. Pathol. Eur.3, 62–79 (1968)
Powell, H., Knox, D., Lee, S., Charters, A. C., Orlott, M., Garrett, R., Lampert, P.: Alloxan diabetic neuropathy: Electron microscopic studies. Neurology (Minneap.)27, 60–66 (1977)
Preston, G. M.: Peripheral neuropathy in the alloxan-diabetic rat. J. Physiol. (Lond.)189, 49–50 (1967)
Reske-Nielsen, E., Lundbaek, K.: Pathological changes in the central and peripheral nervous system of young long-term diabetics. II. The spinal cord and peripheral nerves. Diabetologia4, 34–43 (1968)
Schleapfer, W. W., Gerritson, G. C., Dulin, W. E.: Segmental demyelination in the distal peripheral nerves of chronically diabetic chinese hamsters. Diabetologia10, 541–548 (1974)
Seneviratne, K. N., Peiris, O. A.: The effects of hypoxia on the excitability of the isolated peripheral nerves of the alloxan-diabetic rats. J. Neurol. Neurosurg. Psychiat.32, 462–469 (1969)
Sharma, A. K., Thomas, P. K.: Peripheral nerve structure and function in experimental diabetes. J. Neurol. Sciences23, 1–15 (1974)
Sima, A. A. F.: Studies on fibre size in developing sciatic nerve and spinal roots in normal, undernourished and rehabilitated rats. Acta Physiol. Scand. Suppl.406 (1974)
Skillman, T. G., Johnson, E. W., Hamwi, G. J., Driskill, H. J.: Motor nerve conduction velocity in diabetes mellitus. Diabetes10, 46–51 (1961)
Staats, J.: Diabetes in the mouse due to two mutant genes—a bibliography. Diabetologia11, 325–327 (1975)
Thomas, P. K., Lascelles, R. G.: Schwann cell abnormalities in diabetic neuropathy. Lancet1, 1355–1357 (1965)
Thomas, P. K., Lascelles, R. G.: The pathology of diabetic neuropathy. Q. J. Med.35, 489–509 (1966)
Thomas, P. K., Eliasson, S. G.: Diabetic neuropathy in peripheral neuropathy (eds. Dyck, Thomas, Lambert), Chapt.47. Philadelphia: W. B. Saunders Co. 1975
Author information
Authors and Affiliations
Additional information
Supported by Grant No. MA-5857 from the Medical Research Council of Canada
Rights and permissions
About this article
Cite this article
Sima, A.A.F., Robertson, D.M. Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]. Acta Neuropathol 41, 85–89 (1978). https://doi.org/10.1007/BF00689757
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00689757