Summary
A case of congenital peripheral medullo-epithelioma arising in the sciatic nerve of a 6-month-old boy is reported. Histologically, areas of primitive neural tumor merged with areas showing differentiation into ependymoma, astrocytoma, oligodendroglioma, and ganglioneuroma. These lines of differentiation were confirmed by electron microscopy and immunohistochemistry. Despite the malignant nature of the tumor, 7 years after amputation of the affected leg, the child is alive without recurrence.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Andersen SR (1962) Medulloepithelioma of the retina. Int Ophthalmol Clin 2:483–487
Bailey P, Cushing H (1926) A classification of the tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. Lippincott, Philadelphia
Bolen JW, Thorning D (1980) Peripheral neuroepithelioma: A light and electron-microscopic study. Cancer 46:2456–2462
Cohn I (1928) Epithelial neoplasms of peripheral and cranial nerves. Report of three cases, review of the literature. Arch Surg 17: 117–160
Dastur DK, Lalitha VS (1969) Pathological analysis of intracranial space-occupying lesions in 1,000 cases including children. Part 2. Incidence, types, and unusual cases of glioma. J Neurol Sci 8: 143–170
Deck JHN (1969) Cerebral medulloepithelioma with maturation into ependymal cells and ganglion cells. J Neuropathol Exp Neurol 28:442–454
Eng LF, Vanderhaegan JJ, Bignami A, Gerstl B (1971) An acidic protein isolated from fibrillary astrocytes. Brain Res 28:351–354
Fowler M (1968) Embryonic ependymoma arising in a cerebral hemisphere. Cancer 21:1150–1156
Fujita S (1965) The matrix cell and histogenesis of the central nervous system. Laval Med 36:125–130
Karch SB, Urich H (1972) Medulloepithelioma: Definition of an entity. J Neuropathol Exp Neurol 31:27–53
Pollak A, Friede RL (1977) Fine structure of medulloepithelioma. J Neuropathol Exp Neurol 36:712–725
Russell DS, Rubinstein LJ (1977) Pathology of tumours of the nervous system, 4th edn. Arnold, London, pp 304–305
Scheithauer BW, Rubinstein LJ (1979) Cerebral medulloepithelioma. Report of a case with multiple divergent neuroepithelial differentiation. Childs Brain 5:62–71
Sternberger LA, Hardy PH, Cuculis JJ, Mayer HG (1970) The unlabelled antibody enzyme method of immunohistochemistry. J Histochem Cytochem 18:315–333
Stout AP, Murray MR (1942) Neuroepithelioma of the radial nerve with a study of its behaviour in vitro. Rev Can Biol 1:651–659
Treip CS (1957) A congenital medulloepithelioma of the midbrain. J Pathol Bacteriol 74:357–369
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakamura, Y., Becker, L.E., Mancer, K. et al. Peripheral medulloepithelioma. Acta Neuropathol 57, 137–142 (1982). https://doi.org/10.1007/BF00685381
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00685381