Summary
The intrafascicular contents have been extracted from the tibial nerve of the rabbit through perineurial incisions. Within 6–8 days following this procedure, the perineurial cells separate from one another, become dissociated from their basement membranes and assume a fibroblast-like appearance. The intrafascicular space becomes populated with endoneurial fibroblasts. With the ingrowth of regenerating axons, bundles of axons and associated Schwann cells become surrounded by cells of fibroblastic appearance which undergo perineurial transformation resulting in the development of multiple small fascicles. The cells of the surrounding perineurium appear to reassume a lamellar organization and to reestablish contacts with each other with the formation of junctional complexes. It is therefore suggested that neural structures may be responsible for the development and maintenance of the structural organization of the perineurium.
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Aguavo, A. J., Attiwell, M., Trecarten, J., Perkins, S., Bray, G. M.: Abnormal myelination in transplanted Trembler mouse Schwann cells. Nature265, 73–75 (1977)
Aguayo, A. J., Charron, L., Bray, G. M.: Potential of Schwann cells from unmyelinated nerves to produce myelin: a quantitative ultrastructural and radiographic study. J. Neurocytol.5, 565–573 (1976a)
Aguayo, A. J., Epps, J., Charron, L., Bray, G. M.: Multipotentiality of Schwann cells in cross-anastomosed and grafted myelinated and unmyelinated nerves; quantitatrive microscopy and radioautography. Brain Res.104, 1–12 (1976b)
Ahmed, A.: Reconstitution of the perineurium following nerve grafts. (to be publ.) (1978)
Asbury, A. K.: The biology of Schwann cells. In: Peripheral neuropathy, ed. (P. J. Dyck, P. K. Thomas and E. H. Lambert, vol. 1, pp. 201–212. Philadelphia: Saunders 1975
Davison, A. N., Peters, A.: Mycelination. Springfield, Illinois: Thomas 1970
Denny-Brown, D.: Importance of neural fibroblasts in the regeneration of nerve. Arch. Neurol. (Chic.)55, 171–215 (1946)
Gamble, H. J., Breathnach, A. S.: An electron microscopic study of human foetal peripheral nerves. J. Anat.99, 573–584 (1965)
Gamble, H. J., Eames, R. A.: An electron microscope study of the connective tissues of human peripheral nerve. J. Anat.98, 655–663 (1964)
Hillarp, N. A., Olivecrona, H.: The role played by the axon and the Schwann cells in the degree of myelination of the peripheral nerve. Acta Anat.2, 17–32 (1946)
Masson, P.: Tumeurs encapsulées et benignes des nerfs. Rev. Can. Biol.1, 209–343 (1942)
Reale, E., Luciano, L., Spitznas, M.: Freeze-fracture faces of the perinerrial sheath of the rabbit sciatic nerve. J. Neurocytol.4, 261–270 (1975)
Ross, M. H., Reith, E. J.: Perineurium: evidence for contractile elements. Science165, 604–606 (1969)
Shanthaveerappa, T. R., Bourne, G. H.: The ‘perineurial epithelium’, a metabolically active, continuous, protoplasmic cell barrier surrounding peripheral nerve fasciculi. J. Anat.96, 527–537 (1962)
Shanthaveerappa, T. R., Bourne, G. H.: The effects of transection of the nerve trunk on the perineurial epithelium with special reference to its role in nerve degeneration and regeneration. Anat. Rec.150, 35–50 (1964)
Simpson, S. A., Young, J. Z.: Regeneration of fibre diameter after cross-union of visceral and somatic nerves. J. Anat.79, 48–65 (1945)
Thomas, P. K.: The connective tissue of peripheral nerve. J. Anat.97, 35–44 (1963)
Thomas, P. K.: The morphological basis for alterations in nerve conduction in peripheral neuropathy. Proc. Roy. Soc. Med.64, 13–16 (1971)
Thomas, P. K., Jones, D. G.: The cellular response to nerve injury. 2. Regeneration of the perineurium after nerve section. J. Anat.101, 45–55 (1967)
Thomas, P. K., Olsson, Y.: Microscopic anatomy and function of the connective tissue components of peripheral nerve. In: Peripheral neuropathy, ed. P. J. Dyck, P. K. Thomas and E. H. Lambert, vol. 1, pp. 168–189. Philadelphia: Saunders 1975
Waggener, J. P., Bunn, S. M., Beggs, J.: The diffusion of ferritin within the peripheral nerve sheath. J. Neuropath. exp. Neurol.24, 430–443 (1965)
Weinberg, H. J., Spencer, P. S.: Studies on the control of myelinogenesis. I. Myelination of regenerating axons after entry into a foreign unmyelinated nerve. J. Neurocytol.4, 395–418 (1975)
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Thomas, P.K., Bhagat, S. The effect of extraction of the intrafascicular contents of peripheral nerve trunks on perineurial structure. Acta Neuropathol 43, 135–141 (1978). https://doi.org/10.1007/BF00685008
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DOI: https://doi.org/10.1007/BF00685008