Summary
Cultured cells derived from a psammomatous meningioma were induced to from whorls in vitro by deprivation of nutrients. The ultrastructural features of desmosomes and junctional complexes were similar to sections from the surgical specimen; also prominent were 9–10 nm cytoplasmic filaments. Microelectrode recording of whorled cells showed a larger resting membrane potential than that of similar isolated meningioma cells in culture. Whorl formation seen in this tumor may be a result of relative nutritional deprivation and the need for metabolic cooperation among tumor cells.
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Black, P.M., Liszczak, T. & Kornblith, P.L. Ultrastructural and electrophysiological features of meningioma whorls in tissue culture. Acta Neuropathol 46, 33–38 (1979). https://doi.org/10.1007/BF00684801
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DOI: https://doi.org/10.1007/BF00684801