Summary
The inhibitory effects of the climbing fiber input on cerebellar Purkinje cells was studied in cats.
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1.
The excitatory and the inhibitory effect of the CF input was observed independent from each other.
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At C-T intervals longer than 20 msec the EPSP of the Purkinje cell produced by CF activation was reduced by a preceding inferior olive stimulation.
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3.
At the period of greatest depression of a CF response the N3 wave of a mossy fiber input was not reduced by a conditioning CF input.
It is suggested that basket cells are the interneurons mainly involved in the inhibition of Purkinje cells.
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References
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Supported by the Deutsche Forschungsgemeinschaft.
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Burg, D., Rubia, F.J. Inhibition of cerebellar Purkinje cells by climbing fiber input. Pflugers Arch. 337, 367–372 (1972). https://doi.org/10.1007/BF00586652
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DOI: https://doi.org/10.1007/BF00586652