Summary
Immunisation of mice with SolcoUrovac® vaccine induced an approximately 10-fold increase of the total amount of IgG and a 2-fold increase of IgA immunoglobulins in urine. IgG antibodies to Solco-Urovac antigens appeared in urine after the first injection, and booster injections caused a further increase of the titer. IgA antibodies appeared in the urine after the second injection, and the third injection doubled the titer. IgM immunoglobulins and specific IgM class antibodies to Solco Urovac were not found in any urine tested. The exact origin of the immunoglobulins in the urine as well as the spcificity of immune response is discussed.
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Brooks SJD, Lyons JM, Braude AJ (1974) Immunization against retrograde pyelonephritis. II. Prevention of retrograde Escherichia coli pyelonephritis with vaccine. Am J Pathol 74:359–364
Garg UC, Ganguly NK, Sharma S, Bhatnagar R (1987) Antipiliantibody affords protection against ascending pyelonephritis in rat: evaluated by renal brush border membrane enzymes. Biochem Int 14:517–524
Grischke EM, Rüttgers H (1987) Treatment of bacterial infections of the female urinary tract by immunisation of the patients. Urol Int 42:338–341
Hand WL, Smith JW, Miller TE, Barnett JA, Sanford JP (1970) Immunoglobulin synthesis in lower urinary tract infection. J Lab Clin Med 75:19–29
Hand WL, Smith JW, Sanford JP (1971) The antibacterial effect of normal and infected urinary bladder. J Lab Clin Med 77:605–615
Kaijser B, Olling S (1973) Experimental hematogenous pyelonephritis due to E. coli in rabbits: the antibody response and its protective capacity. J Infect Dis 128:41–49
Kaijser B, Ahlstedt S (1977) Protective capacity of antibodies against Escherichia coli O und K antigens. Infect Immun 17:286–289
Kaijser B, Larsson P, Olling S (1978) Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity. Infect Immun 20:78–81
Källenius G, Svenson SB, Mollby R, Korhonen T, Winberg J, Cedergren B, Helin I, Hultberg H (1982) Carbohydrate receptor structures recognized by uropathogenic E. coli. Scand J Infect Dis [Suppl] 33:52–60
Kauffmann DB, Katz R, McInthosh RM (1970) Secretory IgA in urinay tract infections. Br Med J 4:463–465
Lehmann JD, Smith JW, Miller TE, Barnett JA, Sandford JP (1968) Local immune response in experimental pyelonephritis. J Clin Invest 47:2541–2550
Litschgi M (1987) Treatment of urinary infection with SolcoUrovac (in German). Geburtshilfe Frauenheilkd 2:107–110
Mattsby-Baltzer I, Hanson L, Olling S, Kaijser B (1982) Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli. Infect Immun 35:647–653
Ratner JJ, Thomas VL, Sandford BA, Forland M (1981) Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis. J Infect Dis 143:404–412
Riedasch G, Möhring K (1986) Immunotherapy of recurrent urinary infections in women (in German). Therapiewoche Schweiz 10:896–900
Riedasch G, Möhring K (1987) Is immunotherapy beneficial in chronic bacterial prostatitis? In: Weidner W, Brunner H, Krause W, Rothauge G (eds) Therapy of prostatitis. Zuckschwerdt, München, pp 127–131
Roberts JA, Hardaway K, Kaack B, Fussell EN, Baskin G (1984) Prevention of pyelonephritis by immunization with P-Fimbriae. J Urol 131:602–607
Rüttgers H, Grischke E (1987) Elevation of secretory IgA antibodies in the urinary tract by immunostimulation for the preoperative treatment and post-operative prevention of urinary tract infections. Urol Int 42:424–426
Rumans LW, Vosti KL (1977) Antibody-coated bacteria (letter). JAMA 237:531
Silverblatt FJ, Cohen LS (1979) Antipili antibody affords protection against experimental ascending pyelonephritis. J Clin Invest 64:333–336
Silverblatt FJ, Weinstein R, Rene P (1982) Protection against experimental pyelonephritis by antibodies to pili. Scand J Infect Dis [Suppl] 33:79–82
Smith JW, Wagner S, Swenson RM (1981) Local immune response to E. coli pili in experimental pyelonephritis. Infect Immun 31:17–20
Sohl-Akerlund A, Ahlstedt S, Hanson LA, Jodal U (1979) Antibody responses in urine and serum against Escherichia coli O antigen in childhood urinary tract infection. Acta Pathol Microbiol Scand 87:29–36
Svanborg Eden C, Fasth A, Jodal U (1982) Immunology of urinary tract infection. In: Reevesand DS, Geddes AM (eds) Recent advances in infection. Churchill Livingstone, Edinburgh, pp 141–162
Thomas V, Shelokov A, Forland M (1974) Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med 290:588–590
Uehling DT, Stiehm RM (1971) Elevated urinary secretory IgA in children with urinary tract infection. Paediatrics 47:40–46
Warren JW, Tenney JH, Hoopes JM, Muncie HL, Anthony WC (1982) A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis 146:719–723
Warren JW, Damron D, Tenney JH, Hoopes JM, Deforge B, Muncie HL Jr (1987) Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters. J Infect Dis 155:1151–1158
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Kruze, D., Holzbecher, K., Andrial, M. et al. Urinary antibody response after immunisation with a vaccine against urinary tract infection. Urol. Res. 17, 361–366 (1989). https://doi.org/10.1007/BF00510527
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DOI: https://doi.org/10.1007/BF00510527