Summary
Gamma-glutamyl transpeptidase (y-GT) activity and distribution were investigated in different types of human lung cancers (three epidermoid carcinomas, one large cell carcinoma) which were maintained by serial transplantation in nude mice. All transplanted tumour fragments were positive for the enzyme. In the epidermoid carcinomas, y-GT levels were related to the degree of tumour differentiation. Enzyme activity in tumour fragments was always higher than that found in normal adult human lung tissue, and was, in general, maintained throughout the transplantation series.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Albert, Z.: Gamma-glutamyl transpeptidase in cancers of different human organs. Nature 205, 407 (1965)
Albert, Z., Orlowska, J., Orlowski, M., Szewczuk, A.: Histochemical and biochemical investigations of gamma-glutamyl transpeptidase in the tissues of man and laboratory rodents. Acta Histochem. (Jena) 18, 78–89 (1964)
Albert, Z., Rzucidlo, Z., Starzyk, H.: Biochemical and histochemical investigations of the gamma-glutamyl transpeptidase in embryonal and adult organs of man. Acta Histochem. (Jena) 37, 74–79 (1970)
Aronsen, K.F., Hägerstrand, I., Nordén, J.G., Phil, B.: On the cause of the increased activity of alkaline phosphatase and gamma-glutamyl transpeptidase in serum of patients with liver metastases. Acta Chir. Scand. 135, 619–624 (1969)
Fleming, N., Groscurth, P., Kistler, G.S.: The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human foetal organs. Histochemistry 51, 209–218 (1977)
Glenner, G.G., Folk, J.E., McMillan, P.J.: Histochemical demonstration of a gamma-glutamyl transpeptidase-like activity. J. Histochem. Cytochem. 10, 481–489 (1962)
Goldberg, D.M., Martin, J.V.: Role of y-glutamyl transpeptidase activity in the diagnosis of hepatobiliary disease. Digestion 12, 232–246 (1975)
Kokot, F., Kuska, J., Grzybeck, H., Cekanski, A.: y-glutamyl transpeptidase in tumour diseases. Arch. Immunol. et Ther Exper. 13, 586–592 (1965)
Kreyberg, L.: Histological Typing of Lung Tumours. Geneva: World Health Organization 1967
Povlsen, C.O., Fialkow, P.J., Klein, E., Klein, G., Rygaard, J., Wiener, F.: Growth and antigenic properties of a biopsy — derived Burkitt's lymphoma in thymus—less (nude) mice. Int. J. Cancer 11, 30–39 (1973)
Povlsen, C.O., Visfeldt, J., Rygaard, J., Jensen, G.: Growth patterns and chromosome constitutions of human malignant tumours after long-term serial transplantation in nude mice. Acta path microbiol. scand. Sect. A. 83, 709–716 (1975)
Rutenburg, A.M., Pineda, E.P., Fischbein, J., Goldbarg, J.A.: A study of serum peptidases in anicteric patients with cancer. Cancer 17, 781–784 (1964)
Rutenburg, A.M., Kim, H., Fischbein, J.W., Hanker, J.S., Wasserkrug, H.L., Seligman, A.M.: Histochemical and ultrastructural demonstration of y-glutamyl transpeptidase activity. J. Histochem. Cytochem. 17, 517–526 (1969)
Shimosato, Y., Kameya, T., Nagai, K., Hirohashi, S., Koide, T., Hayashi, H., Nomura, T.: Transplantation of human tumours in nude mice. J. Nat. Cancer. Inst. 56, 1251–1260 (1976)
Sordat, B., Fritsche, R., Mach, J.-P., Carrel, S., Ozzello, L., Cerottini, J.-C.: Morphological and functional evaluation of human solid tumours serially transplanted in nude mice. Proceedings of the First International Workshop on Nude Mice (ed. Rygaard, J., Povlsen, C.O.), Stuttgart: Gustav Fischer Verlag 1974
Szasz, G.: A kinetic photometric method for serum y-glutamyl transpeptidase. Clin. Chem. 15, 124–136 (1969)
Weichselbaum, T.E.: Determination of proteins in blood serum and plasma. Amer. J. Clin. Path. 16, 40–49 (1946)
Wise, K.S., Müller, E.: y-glutamyl transpeptidase in human nephroblastoma grown in nude mice. Experientia (Basel) 32, 294–296 (1976)
Author information
Authors and Affiliations
Additional information
This work was supported by a grant from A.S.F.C., Switzerland, and the Jubiläumsspende 1970 der Zürcher Kantonalbank
N.F. was supported during part of the work by a Royal Society European Science Exchange Programme Fellowship
Rights and permissions
About this article
Cite this article
Groscurth, P., Fleming, N. & Kistler, G.S. The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human lung cancers serially transplanted in nude mice. Histochemistry 53, 135–142 (1977). https://doi.org/10.1007/BF00498488
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00498488