Summary
In the treatment of patients with sudden deafness, we found no significant difference between an oral calcium antagonist (nifedipine) and intravenous naftidrofuryl given concomitantly with vitamin A, vitamin E, and zinc. This prospective randomized study in 50 patients again shows that recovery to useful hearing levels tends to be spontaneous and independent of the type of medical treatment given. Irrespective of their capability to prevent contractions of cerebral vascular smooth muscle induced by neurotransmitter and vasoconstrictor substances and of their rheological properties, currently available calcium antagonists of the nifedipine type are unable to enhance hearing recovery at the present time.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Byl FM (1978) Sudden hearing loss research clinic. Otolaryngol Clin North Am 11:71–79
Fisch U (1983) Management of sudden deafness. Otolaryngol Head Neck Surg 91:3–8
Fleckenstein A (1983) Calcium antagonism in heart and smooth muscle. Wiley, New York
Handrock M, Berghaus A (1984) Hörsturztherapie mit einem Calciumantagonisten. Praxiskurier 19:28
Haug O, Draper WL, Haug SA (1976) Stellate ganglion blocks for idiopathic sensorineural hearing loss. Arch Otolaryngol 102:766–784
Kazda S, Knorr A, Towart R (1983) Common properties and differences between various calcium antagonists. Progress in pharmacology, 5/2. Fischer, Stuttgart, pp 83–116
Lossnitzer K, Pfennigsdorf G, Bräuer H (1983) Myokard, Gefäße, Calcium. Knoll AG, Ludwigshafen
Mattox DE, Simmons FB (1977) Natural history of sudden sensorineural hearing loss. Ann Otol 86:463–480
Morgenstern C, Setz J, Jesdinsky J, Vosteen KH (1983) Zur Therapie des akuten Hörverlustes. HNO 32:128–131
Otto PC, Kellerhals B (1976) Zur Behandlung des akuten Hörsturzes. HNO 24:113–115
Theisen JM, Mann W, Ino T, Schmidt CL, Eibach H (1979) Anmerkungen zur Infusionstherapie bei einem akuten Hörsturz. Arch Otorhinolaryngol 223:241–243
Towart R, Kazda S (1982) Preferential vasodilator actions of the calcium antagonists nimodipine, nifedipine and verapamil on contractions of cerebral vascular smooth muscle included by neurotransmitter and vasoconstrictor substances. In: Heistad DD, Marus ML (eds) Cerebral blood flow: effects of nerves and neurotransmitters. Elsevier/North Holland, Amsterdam
Weinaug P (1984) Die Spontanremission beim Hörsturz. HNO 32:346–351
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mann, W., Beck, C. & Beck, C. Calcium antagonists in the treatment of sudden deafness. Arch Otorhinolaryngol 243, 170–173 (1986). https://doi.org/10.1007/BF00470614
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00470614