Abstract
Clinical, morphological, ultrastructural and immunological studies were performed in a case of congenital self-healing non-Langerhans cell histiocytosis. The patient showed several aspects that have not been published before: a large nodule in the vulvar region, vesiculobullous elements and pneumonia (asymptomatic). The relationship of the vesicles and pneumonia to the histiocytic disorder is not clear. Ultrastructurally, worm-like (comma-shaped) particles, dense bodies and Birbeck granules were not found. Histiocytes were Leu-6 negative, and S100 (partly), Leu M3 and HLA-DR positive. Positive reactions were also obtained with anti-lysozyme and non-specific esterase. Several aspects of this case and of others described previously are discussed.
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Oranje, A.P., Vuzevski, V.D., de Groot, R. et al. Congenital self-healing non-Langerhans cell histiocytosis. Eur J Pediatr 148, 29–31 (1988). https://doi.org/10.1007/BF00441808
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DOI: https://doi.org/10.1007/BF00441808