Summary
The authors analyzed rapid oscillations of blood sugar (GL) and free fatty acid levels (FFA) in serum of healthy subjects. They investigated a series of blood samples taken under conditions of absolute rest from the cubital vein at 15-s intervals for a period of 6 min. In addition to common statistical parameters, they calculated the course of autocorrelation and cross-correlation functions and periodograms. The magnitude of oscillations is significantly higher than the error of the biochemical methods. In some sequences periodicities were detected which were statistically significant in 23.8% of GL and in 38.1% of FFA. 24-point series of GL collected in parallel from both arms correlate in 36.3% positively, in 27.3% negatively, and in 36.4% they do not correlate. Series of FFA and GL collected simultaneously from one site correlate mutually in almost all instances either positively or negatively, frequently with a time shift. The oscillations may be due to (a) feedback regulations of the levels of the two metabolites, (b) permanent mutual interaction between the FFA and glucose level and (c) an uneven concentration of the two metabolites in different parts of the circulation. The above factors may combine, and the list of possible factors may not be complete.
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References
AndĚl, J.: Statistical analysis of time series (in Czech.). Prague: SNTL 1976
Bessman, S. P., Beigelman, P. M., Thomas, L. J., Jr.: The periodicity of insulin secretion by islets of Langerhans shown by using a new apparatus. Preliminary data. Biochem. Med. 7, 97–102 (1973)
Chance, B., Schooner, B.: Control of oscillations of the DPNH level in cell free extract of Saccharomyces carlsbergensis by 3′5′cyclic AMP. Biochem. Biophys. Res. Comun. 17, 416–423 (1964)
Court, J. M., Dunlop, M. E., Leonard, R. F.: High-frequency oscillation of blood free fatty acid levels in man. J. Appl. Physiol. 31, 345–347 (1971)
Dole, V. P.: A relation between NEFA in plasma and the metabolism of glucose. J. Clin. Invest. 35, 150–154 (1956)
Editorial: Das Prostaglandin-Thromboxan-System. Schweiz. Med. Wochenschr. 107, 753–756 (1977)
Eisenstein, A. B., Singh, S. P.: Hormonal control of nutrient metabolism. V: Modern nutrition in health and disease (eds. R. S. Goodhard and M. E. Shils). Philadelphia: Lea and Febiger 1973
Fisher, R. A.: Tests of significance in harmonic analysis. Proc. Roy. Soc. A (Lond.) 125, 54–59 (1929)
Ghosh, A., Chance, B.: Oscillations of glycolytic intermediates in yeast cells. Biochem. Biophys. Res. Commun. 16, 174–181 (1964)
Goldbetter, A., Lefever, R.: Dissipative structures for an allosteric model, application to glycolytic oscillations. Biophys. J. 12, 1302 (1972)
Hansen, K.: Oscillations in the blood sugar in fasting normal persons. Acta Med. Scand. [Suppl.] 4, 27 (1923)
Horton, E. W.: Hypotheses of the physiological role of prostaglandins. Physiol. Rev. 49, 122–161 (1969)
Iberall, A., Ehrenberg, M., Cardon, S., Simenoff, M.: High frequency glucose oscillations in man. Metabolism 17, 1119–1121 (1968)
Lefevbre, P. J., Unger, R. H.: Glucagon: Molecular physiology, clinical and therapeutical implications. New York: Pergamon Press 1970
Leonov, J. P., Rajevskij, S. J., Rajbman, N. S.: On the use of statistical dynamics in automatisation (in Czech.). Prague: SNTL 1965
Milsum, J. H.: Biological control systems analysis. New York: McGraw-Hill 1966
Oppelt, W.: Kleines Handbuch technischer RegelvorgÄnge. Weinheim: Verlag Chemie 1964
Randle, P. J., Garland, P. B., Hales, C. N., Newsholme, E. A.: The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet I, 785–789 (1963)
Sollberger, A.: Biological rhytm research. Amsterdam, London, New York: Elsevier 1965
Symposium: Spectral analysis of the spontaneous fluctuations in the circulation. 39th Ann. Meeting of Czech. Physiol. Soc., Prague, February 1977
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Brodan, V., Hájek, M., Kuhn, E. et al. Analysis of rapid oscillations of glucose and free fatty acids in plasma. Europ. J. Appl. Physiol. 41, 159–171 (1979). https://doi.org/10.1007/BF00430008
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DOI: https://doi.org/10.1007/BF00430008