Abstract
The hemodynamic effect of timolol maleate in open angle glaucoma was studied rheo-oculographically.
Increase in the ocular pulse which reaches maximal amplification 2 h after the instillation of the drug was observed.
The maximal pressure lowering effect appeared 3 h after instillation, as if the hemodynamic effect were the trigger for the pressure lowering effect.
Zusammenfassung
Mit der rheo-okulographischen Methode untersuchten die Verff. die haemo-dynamische Wirkung des Timolol-Maleats bei Glaukom mit offenem Kammerwinkel.
Sie konnten in allen Fällen eine Zunahme des Augenpulses beobachten, dessen größter Ausschlag 2 h nach Instillierung des Mittels auftrat.
Die größte druckherabsetzende Wirkung wurde erst nach 3 h festgestellt, als ob die haemo-dynamische Wirkung den Trigger für den druckherabsetzenden Effekt darstellte.
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Cristini, G., Giovannini, A. Pressure lowering effect of timolol with reference to its topical vascular action. Albrecht von Graefes Arch. Klin. Ophthalmol. 211, 325–328 (1979). https://doi.org/10.1007/BF00414691
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DOI: https://doi.org/10.1007/BF00414691