Summary
Using a microperfusion technique proximal tubular reabsorption of sulfamerazine, phenobarbital, p-aminohippuric acid, uric acid, sulfaurea and N4-acetylsulfamerazine was studied as a function of intratubular pH in the rat kidney in vivo. Transtubular permeabilities were related to in vitro lipoid solubility measurements and degrees of non-dissociation of the acids. It was found that
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1.
sulfamerazine and phenobarbital exhibit nonionic backdiffusion, the magnitude of which is dependent on lipoid solubility,
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2.
p-aminohippuric acid, uric acid and sulfaurea do not show this backdiffusion, a finding explained by lack of lipoid solubility,
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3.
N4-acetylsulfamerazine, despite relatively high lipoid solubility, is not reabsorbed in the proximal tubule.
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Supported by NIH-Grant AM 06806-03 and the Deutsche Forschungsgemeinschaft.
Parts of this investigation have been reported at the meetings of the Deutsche Physiologische Gesellschaft, Bad Nauheim, 196419 and the American Physiological Society, Providence, 196420.
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Sonnenberg, H., Oelert, H. & Baumann, K. Proximal tubular reabsorption of some organic acids in the rat kidney in vivo. Pflügers Archiv 286, 171–180 (1965). https://doi.org/10.1007/BF00363859
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DOI: https://doi.org/10.1007/BF00363859