Summary
With the use of monoclonal antibodies, raised against the human polyglucosan, positive staining of polyglucosan bodies (PGB) was detected in the brain, spinal cord and cecum of aged dogs. PGB in feline brain were also positively stained with these antibodies. These findings indicate that animal PGB share common antigenicity with human PGB.
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Atoji Y, Hori Y, Suzuki Y, Sugimura M (1987) Lectin histochemistry of canine polyglucosan bodies. Acta Neuropathol (Berl) 73:177–180
Hsu S-M, Raine L, Fanger H (1981) The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique. A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Kamiya S, Suzuki Y, Sugimura M (1983) Polyglucosan bodies in the digestive tract of the aged dog. Acta Neuropathol (Berl) 60:297–300
Kamiya S, Suzuki Y (1989) Polyglucosan bodies in the brain of the cat. J Comp Pathol 101:263–267
Liu HM, Anderson K, Caterson B (1987) Demonstration of a keratan sulfate proteoglycan and mannose-rich glycoconjugate in corpora amylacea of the brain by immunocytochemical and lectin-binding methods. J Neuroimmunol 14:49–60
Robitaille Y, Carpenter S, Karpati G, DiMauro S (1980) A distinct form of adult polyglucosan body disease with massive involvement of central and peripheral neuronal process and astrocytes. A report of four cases and a review of the occurrence of polyglucosan bodies in other conditions, such as Lafora's discase and normal ageing. Brain 103:315–336
Suzuki Y, Akiyama K, Suu S (1978) Lafora-like bodies in the CNS of aged dogs. Acta Neuropathol (Berl) 44:217–222
Van Heycop Ten Ham MW (1974) Lafora disease. A form of progressive myoclonus epilepsy. Handb Clin Neurol 15:382–422
Yokota T, Ishihara T, Kawano H, Yamashita Y, Takahashi M, Uchino F, Kamei T, Kusunose Y, Yamada M, Matsumoto N (1987) Immunological homogeneity of Lafora body, corpora amylacea, basophilic degeneration in heart, and intracytoplasmic inclusions of liver and heart in type IV glycogenosis. Acta Pathol Jpn 37:941–946
Yokota T, Ishihara T, Yoshida H, Takahashi M, Uchino F, Hamanaka S (1988) Monoclonal antibody against polyglucosan isolated from the myocardium of a patient with Lafora disease. J Neuropathol Exp Neurol 47:572–577
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Kamiya, S., Suzuki, Y. & Daigo, M. Immunoreactivity of canine and feline polyglucosan bodies for monoclonal antibody against human polyglucosan. Acta Neuropathol 81, 217–218 (1990). https://doi.org/10.1007/BF00334511
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DOI: https://doi.org/10.1007/BF00334511