Summary
The nucleating effect of hydroxyapatite (HAP) and the inhibitory effect of pyrophosphate (PPi) on calcium oxalate crystallization have been studied at different pH's in solution metastabely supersaturated with respect to calcium oxalate but saturated with respect to HAP. Crystallization was monitored by a decrease of calcium in the supernatant and formation products were calculated. At a pH above 6.0 already minimal HAP concentrations proved to be a suitable substrate for heterogeneous nucleation and growth of calcium oxalate. PPi showed a pronounced inhibitory effect on spontaneous as well as on HAP induced crystallization of calcium oxalate, this effect being highly pH dependent. HAP was found to neutralize the inhibitory effect of PPi in a molar ratio of 10:1.
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Baumann JM, Lauber K, Lustenberger FX, Wacker M, Zingg EJ (1985) Crystallization conditions in urine of patients with idiopathic recurrent calcium nephrolithiasis and with hyperparathyroidism. Urol Res 13:169–174
Baumann JM, Ackermann D (1988) Inhibition of calcium phosphate crystallization. In: Martelli A, Buli P, Marchesini B (eds) Inhibitors of crystallization in renal lithiasis and their clinical application. Acta Medica pp 83–88
Finlayson B, Reid F (1978) The expectation of free and fixed particles in urinary stone disease. Invest Urol 15:442–448
Koutskoukos PG, Sheehan ME, Nancollas GH (1981) Epitaxial considerations in urinary stone formation. II. The oxalate phosphate system. Invest Urol 18:358–363
Meyer JL, Bergert JH, Smith LH (1975) Epitaxial relationships in urolithiasis: the calcium oxalate monohydrate hydroxyapatite system. Clin Sci Mol Med 49:369–374
Pak CYC, Hayashi Y, Arnold LH (1976) Heterogenous nucleation with urate, calcium phosphate and calcium oxalate. Proc Soc Exp Biol Medi 153:83–87
Pak CYC, Fuller C, Sakhaee K, Preminger GM, Britton F (1985) Long-term treatment of calcium nephrolithiasis with potassium citrate. 134:11–19
Randall A (1937) The origin and growth of renal calculi. Am Surg 105:1009
Wikström B, Danielson BG, Ljunghall S, McGuire M, Russell RGG (1983) Urinary pyrophosphate excretion in renal stone formers with normal and impaired renal acidification. World J Urol 1:150–154
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Baumann, J.M., Ackermann, D. & Affolter, B. The influence of hydroxyapatite and pyrophosphate on the formation product of calcium oxalate at different pHs. Urol. Res. 17, 153–155 (1989). https://doi.org/10.1007/BF00256242
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DOI: https://doi.org/10.1007/BF00256242