Summary
The somatotopic inputs into fastigial cells have been studied in relation to cutaneous mechanoreceptors of forelimb and hindlimb. Some fastigial cells were very discriminative, not only in respect of the limb, but also to restricted areas of hairy skin and related toe pads. Others were much less so, forelimb and hindlimb cutaneous receptors evoking similar excitatory-inhibitory responses. In addition, from the contralateral hindlimb, responses were evoked which were comparable with those from the ipsilateral limb.
Somatotopic diagrams have been constructed which show in four experiments the sites of fastigial cells in the parasagittal plane of the microelectrode tracks. For each experiment four separate plottings give a comparison of the sizes of responses evoked for forelimb and hindlimb: excitation from nerve volleys; inhibition from nerve volleys; excitation from pad taps; inhibition from pad taps. In this way it is shown that fastigial cells with similar somatotopic relations often occur in clusters, particularly when assessed by their inhibitory responses.
Since fastigial inhibition is largely due to Purkyně cells, there is an attempt to correlate the somatotopic relations of Purkyně cells with the somatotopy of fastigial cell inhibition. The excitation of fastigial cells exhibits less somatotopic discrimination, which conforms with the poor somatotopic discrimination of cells of the lateral reticular nucleus.
In a final discussion there is consideration of two principal projections from the vermis of the anterior lobe: Purkyně cells inhibiting Deiters neur; Purkyně cells inhibiting fastigial cells which in turn monosynaptically excite Deiters neurones, the inhibition of Deiters neurones being then by disfacilitation. The degree of forelimb-hindlimb convergence in these pathways is reconsidered and is diagrammatically illustrated.
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Allen, G.I., Sabah, N.H., Toyama, K.: Synaptic actions of peripheral nerve impulses upon Deiters neurones via the climbing fibre afferents. J. Physiol. (Lond.) 226, 311–333 (1972a)
Allen, G.I., Sabah, N.H., Toyama, K.: Synaptic actions of peripheral nerve impulses upon Deiters neurones via the mossy fibre afferents. J. Physiol. (Lond.) 226, 335–351 (1972b)
Batini, C., Pompeiano, O.: Chronic fastigial lesions and their compensation in the cat. Arch. ital. Biol. 95, 147–165 (1957)
Batini, C., Pompeiano, O.: Effects of rostro-medial and rostro-lateral fastigial lesions on decerebrate rigidity. Arch. ital. Biol. 96, 315–329 (1958)
Brodal, A., Pompeiano, O., Walberg, F.: The Vestibular Nuclei and Their Connections, Anatomy and Functional Correlations. Edinburgh-London: Oliver & Boyd 1962
Chambers, W.W., Sprague, J.M.: Functional localization in the cerebellum. I. Organization in longitudinal cortico-nuclear zones and their contributions to the control of posture both extrapyramidal and pyramidal. J. comp. Neurol. 103, 105–129 (1955a)
Chambers, W.W., Sprague, J.M.: Functional localization in the cerebellum. II. Somatotopic organization in cortex and nuclei. Arch. Neurol. Psychiat. (Chic.) 74, 653–680 (1955b)
Dow, R.S., Moruzzi, G.: The Physiology and Pathology of the Cerebellum. Minneapolis: The University of Minnesota Press 1958
Eager, R.P.: Efferent cortico-nuclear pathways in the cerebellum of the cat. J. comp. Neurol. 120, 81–103 (1963)
Eccles, J.C.: Functional significance of arrangement of neurones in cell assemblies. Arch. Psychiat. Nervenkr. 215, 92–106 (1971)
Eccles, J.C.: The cerebellum as a computer: Patterns in space and time. J. Physiol. (Lond.) 229, 1–32 (1973)
Eccles, J.C., Faber, D.S., Murphy, J.T., Sabah, N.H., Táboříková, H.: Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. II. In Purkyně cells. Exp. Brain Res. 13, 36–53 (1971a)
Eccles, J.C.: Investigations on integration of mossy fiber inputs to Purkyně cells in the anterior lobe. Exp. Brain Res. 13, 54–77 (1971b)
Eccles, J.C., Ito, M., Szentágothai, J.: The Cerebellum as a Neuronal Machine. pp. 335. Heidelberg-Berlin-New York: Springer 1967
Eccles, J.C., Provini, L., Strata, P., Táboříková, H.: Topographical investigations on the climbing fiber inputs from forelimb and hindlimb afferents to the cerebellar anterior lobe. Exp. Brain Res. 6, 195–215 (1968)
Eccles, J.C., Sabah, N.H., Schmidt, R.F., Táboříková, H.: Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. II. In Purkyně cells by mossy fiber input. Exp. Brain Res. 15, 261–277 (1972a)
Eccles, J.C.: Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. III. In Purkyně cells by climbing fiber input. Exp. Brain Res. 15, 484–497 (1972b)
Eccles, J.C.: Integration by Purkyně cells of mossy and climbing fiber inputs from cutaneous mechanoreceptors. Exp. Brain Res. 15, 498–520 (1972c)
Eccles, J.C., Táboříková, H.: Responses evoked in neurones of the fastigial nucleus by cutaneous mechanoreceptors. Brain Res. 35, 523–527 (1971)
Eccles, J.C.: Excitatory and inhibitory responses of neurones of the cerebellar fastigial nucleus. Exp. Brain Res. 19, 61–77 (1974a)
Eccles, J.C.: The pathways responsible for excitation and inhibition of fastigial neurones. Exp. Brain Res. 19, 78–99 (1974b)
Ito, M., Kawai, N., Udo, M.: The origin of cerebellar-induced inhibition of Deiters neurones. III. Localization of the inhibitory zone. Exp. Brain Res. 4, 310–320 (1968)
Ito, M., Udo, M., Mano, N., Kawai, N.: Synaptic action of the fastigio-bulbar impulse upon neurones in the medullary retieular formation and vestibular nuclei. Exp. Brain Res. 11, 29–47 (1970)
Ito, M., Yoshida, M.: The origin of cerebellar-induced inhibition of Deiters neurones. I. Monosynaptic initiation of the inhibitory postsynaptic potentials. Exp. Brain Res. 2, 330–349 (1966)
Ito, M., Obata, K., Kawai, N., Udo, M.: Inhibitory control on intracerebellar nuclei by the Purkinje cell axons. Exp. Brain Res. 10, 64–80 (1970)
Jansen, J.: Efferent csrebellar connections. In: Aspects of Cerebellar Anatomy, pp. 189–248. Ed. by J. Jansen and A. Brodal. Oslo: Johan Grundt Tanum Forlag 1954
Jansen, J., Brodal, A.: Experimental studies on the intrinsic fibers of the cerebellum. II. The corticonuclear projection. J. comp. Neurol. 73, 267–321 (1940)
Kitai, S.T., Táboříková, H., Tsukahara, N., Eccles, J.C.: The distribution to the cerebellar anterior lobe of the climbing and mossy fiber inputs from the plantar and palmar cutaneous afferents. Exp. Brain Res. 7, 1–10 (1969)
Oscarsson, O.: Functional significance of information channels from the spinal cord to the cerebellum. In: Neurophysiological Basis of Normal and Abnormal Motor Activities, pp. 93–108. Ed. by M.D. Yahr and D.P. Purpura. New York: Raven Press 1967
Oscarsson, O.: Functional organization of spinocerebellar paths. In: A. Iggo (Ed.), Handbook of Sensory Physiology, Vol. II, Somato-sensory System. pp. 339–380. Berlin-Heidelberg-New York: Springer 1973
Pompeiano, O.: Functional organization of the cerebellar projections to the spinal cord. In: Progress in Brain Research, Vol. 25, pp. 282–321. Ed. by C. A. Fox and R. S. Snider. Amsterdam: Elsevier Publishing Company 1967
Rosén, I., Scheid, P.: Patterns of afferent input to the lateral retieular nucleus of the cat. Exp. Brain Res. 18, 242–255 (1973a)
Rosén, I., Scheid, P.: Responses to nerve stimulation in the bilateral ventral flexor reflex tract (bVFRT) of the cat. Exp. Brain Res. 18, 256–267 (1973b)
Rosén, I., Scheid, P.: Responses in the spino-reticulo-cerebellar pathway to stimulation of cutaneous mechanoreceptors. Exp. Brain Res. 18, 268–277 (1973c)
Walberg, F., Jansen, J.: Cerebellar corticonuclear projection studied experimentally with silver impregnation method. J. Hirnforsch. 6, 338–354 (1964)
Walberg, F., Pompeiano, O., Brodal, A., Jansen, J.: Fastigiovestibular fibers in the cat. An experimental study with silver methods. J. comp. Neurol. 118, 49–76 (1962)
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Eccles, J.C., Rantucci, T., Sabah, N.H. et al. Somatoiopic studies on cerebellar fastigial cells. Exp Brain Res 19, 100–118 (1974). https://doi.org/10.1007/BF00233397
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DOI: https://doi.org/10.1007/BF00233397