Summary
The new potential tetradentate ligand N-salicyl-N′-thiobenzohydrazide (H2SBTH) and its Cu complex, [Cu(SBTH)], have been prepared and characterized by physico-chemical studies. In vivo antitumour activity of [Cu(SBTH)] has been tested against breast tumour in C3H/J strain mice; LD 50 values were also calculated. The cytotoxicity and antitumour effect of [Cu(SBTH)] is a maximum at 100 mg kg-1 body weight injected intraperitoneally in mice carrying breast tumour. In vitro results of the ligand and the complex on P-815 (murine mastocytoma) and K-562 (human erythroleukemia cells) indicate that these compounds show significant inhibition on 3H-thymidine and 3H-uridine incorporation in DNA and RNA in these tumour cells. Light microscopic study of the treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasmic boundaries, take place in complex-treated mice with tumours.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
H. G. Petering, H. H. Buskirk and J. A. Crim, Cancer Res., 27, 1115 (1967).
J. A. Crim and H. G. Petering, Cancer Res., 27, 1278 (1967).
P. Mikelens, B. Woodson and W. Levinson, Biochem. Pharmacol., 24, 821 (1976).
W. Levinson and R. Helling, Antimicrobial Agents and Chemotherapy, 9, 160 (1976).
W. Kaska, C. Carrono, J. Michaelwski and W. Levinson, Unpublished work.
E. J. Blanz, F. A. French, D. Amaral and D. A. French, J. Med. Chem., 13, 1124 (1970).
F. A. French, E. J. Blanz, S. C. Shaddix and R. N. Brockman, J. Med. Chem., 17, 172 (1974).
A. Sartorelli, Biochem. Biophys. Res. Commun., 27, 26 (1967).
E. C. Moore, B. A. Booth and A. C. Santorelli, Cancer Res., 31, 235 (1971).
T. Curtuis and H. Melsbash, J. Prakt. Chem., 81, 545 (1910); T. Curtuis and H. Melsbash, Chem. Abstr., 4, 2632 (1910).
K. A. Jensen and C. Pederson, Acta Chem. Scand., 15, 1097 (1961).
N. K. Singh, Nagendra Singh and G. C. Prasad, Transition Met. Chem., 21, (1996).
N. K. Singh, S. Agrawal and R. C. Aggarwal, Indian J. Chem., 21A, 973 (1982).
A. Sodhi and S. M. Singh, Int. J. Immunopharmacol., 8, 701 (1986).
S. E. Livingstone, Proc. 20th Conf. Coordination Chem., Calcutta, India, 1980, p. 141.
I. M. Proctor, B. J. Hathaway and P. Nicholla, J. Chem. Soc., A, 1978 (1968).
T. R. Felthouse and D. N. Hendrickson, Inorg. Chem., 17, 444 (1978).
K. Geetharani and D. N. Sathyanarayana, Aust. J. Chem., 30, 1617 (1977).
G. R. Burns, Inorg. Chem., 7, 277 (1968).
E. Sinn and C. M. Harris, Coord. Chem. Rev., 4, 391 (1969).
R. M. Silverstein, G. C. Bassler and C. Morill, Spectrometric Identification of Organic Compounds, 4th Edit., Wiley, New York, 1981, p. 196.
P. D. Omiano, C. Pelizzi, G. Predieri, C. Vignali and G. Palla, Polyhedron, 3, 281 (1984).
A. Sodhi and S. K. Aggarwal, J. Natl. Cancer Inst., 53, 85 (1974).
S. Sarna and A. Sodhi, Indian J. Exp. Biol., 16, 1236 (1978).
S. Agrawal, N. K. Singh, R. C. Aggarwal, A. Sodhi and P. Tandon, J. Med. Chem., 29, 199 (1986).
A. F. French and J. E. Blanz Jr, Cancer Res., 26, 1638 (1966).
M. Mohan, P. Sharma and N. K. Jha, Inorganic Chimica Acta, 106, 117 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Singh, N.K., Singh, N., Sodhi, A. et al. Synthesis, characterization and antitumour studies on N-salicyl-N′-thiobenzohydrazide and its copper(II) complex. Transition Met Chem 21, 556–559 (1996). https://doi.org/10.1007/BF00229712
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00229712