Summary
The rules defining the Asp-Asp domain of RNA-dependent polymerases deduced by Argos (1988) were tested in a set of 53 putative reverse transcriptases (RTs) sequences. Since it was found that some of these rules are not followed by RTs coded by bacteria, group 11 introns, and non-LTR retrotransposons, we present here a more strict definition of the Asp-Asp domain.
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Abbreviations
- RT:
-
reverse transcriptase
- DD:
-
Asp-Asp
- ORF:
-
open reading frame
- mt:
-
mitochondria
- pt:
-
plastid
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Velasco, A.M., Medrano, L., Lazcano, A. et al. A redefinition of the Asp-Asp domain of reverse transcriptases. J Mol Evol 35, 551–556 (1992). https://doi.org/10.1007/BF00160216
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DOI: https://doi.org/10.1007/BF00160216