Summary
The effect of RhCl3 on DNA helix conformation was studied by circular dichroism spectroscopy and compared to the behaviour of Me2SnCl2 and TINO3; the latter metal-DNA systems have been further studied by ultraviolet and thermal denaturation techniques. Both rhodium(III) and tin(IV) react with the bases of DNA and induce appreciable alterations of the double-helical conformation. Rhodium(III) at low binding ratio causes a stabilization of the DNA B conformation, while at higher structural changes are interpreted in terms of a B to C transition. Tin(IV) produces a ψ form geometry; only at high binding ratios does interaction with the phosphate groups seem to occur. The data for thallium(I) are interpreted in terms of a preferential interaction with the phosphate groups of the DNA chain, causing a stabilization of the double-helical structure of DNA.
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Koutsodimou, A., Katsaros, N. & Kovala-Demertzi, D. The interaction of rhodium(III) with DNA by circular dichroism studies. Comparative behaviour of dimethyltin(IV) and thallium(I). Transition Met Chem 19, 260–264 (1994). https://doi.org/10.1007/BF00139088
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DOI: https://doi.org/10.1007/BF00139088