Summary
In streptomycin (SM)-producing organisms, the lower affinity of ribosomes for SM gives rise to a lower susceptibility of protein synthesis to SM. But, even in a strain with considerably low affinity of ribosomes for SM, phosphorylation of SM in the cells by SM 6-kinase is necessary for the protein synthesis to be fully tolerant to SM.
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Sugiyama, M., Mochizuki, H., Nimi, O. et al. Roles of streptomycin 6 -kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer. Biotechnol Lett 3, 357–362 (1981). https://doi.org/10.1007/BF00127618
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DOI: https://doi.org/10.1007/BF00127618