Fifty-four cylinders (2.8 mm in diameter) machined from hot isostatically pressed titania (TI) and titania-hydroxyapatite (TI/HA-15 vol%) sintered at 925°C, as well as commercially pure titanium (c.p. Ti), were implanted in the fermoral cortical bone of New Zealand white rabbits for 1, 3 and 12 months. The shear strength between bone and implant was measured by a push-out test. The TI/HA composite showed a significantly higher bonding strength to bone compared to c.p. Ti at all times, while no differences were observed between TI and c. p. Ti at 1 and 3 months after implantation. Titania-based materials had a significantly higher bonding strength than that of c.p. Ti one year after implantation. The results indicate that bioactivity of HA in TI/HA composite contributes to the early bone apposition reflected by high bonding strength, while the stability of the oxide, determines the development of long-term bonding strength. Both effects may be explained by the level and type of ions released from the ceramic implant. HA has a positive conduction to bone ingrowth while TI has a limited interaction to the bone apposition due to the extraordinary low ion release in vivo. Under light microscopy, similar patterns of bone-implant interfaces were seen from titania-based materials and c.p. Ti in 3-month samples, indicating high biocompatibility of these materials. However, histological evaluation by light microscope cannot identify the differences between physical contact and chemical bonding of implant-bone interface, and thus does not give information on bonding mechanism and the level of shear stresses developed.
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References
D. ADAMS and D. WILLIAMS, Dental Update 12 (1985) 241–249.
P. BRÅNEMARK, G. ZARB and T. ALBREKTSSON, in “Introduction to osseointegration” (Quintessence, Pub. Co. 1985).
M. JARCHO, Clin. Orthop. 157 (1981) 259–278.
A. WISBEY, P. GREGSON, L. PETER and M. TUKE, Biomaterials 12 (1991) 470–473.
T. HANAWA, in “The bone-biomaterial interface”, edited by J. E. DAVIES (University of Toronto Press, Toronto, 1991) pp. 49–61.
P. TENGVALL and I. LUNDSTRÖM, Clin. Mater. 9 (1992) 115–134.
M. THERIN, A. MEUNIER and P. CHRISTEL, J. Mater. Sci.: Mater. Med. 2 (1991) 1–8.
A. ERIKSSON, PhD thesis, University of Gothenburg, Sweden (1984).
J. LI, PhD thesis, Karolinska Institute, Sweden (1992).
E. SCHEPERS, M CLERCQ and P. DUCHEYNE, in “Implant materials in biofuction”, edited by C.De PUTTER, G.De LANGE, K.De GROOT and A. LEE (Elsevier Science Publisher B.V., Amsterdam, 1987) pp. 79–85.
F. BOSSA, B. LOOMAN, R. PIETRA, E. SABBIONI, M. GALLORINI and E. ORVIN, in “Ceramics in clinical applications”, edited by P. VINCENZINI (Elsevier, Amsterdam, 1987) p. 99–109.
P. BRÅNEMARK U. BREINE, R. ADELL, B. HANSSON, J. LINDSTRÖM and Å. OHLSSON, Scand. J. Plast. Reconstr. Surg. 3 (1969) 81–100.
C. MICHAELS, J. KELLER and C. STANFORD, J. Oral Impl. 17 (1991) 132–139.
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Fartash, B., Liao, H., Li, J. et al. Long-term evaluation of titania-based ceramics compared with commercially pure titanium in vivo . J Mater Sci: Mater Med 6, 451–454 (1995). https://doi.org/10.1007/BF00123369
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DOI: https://doi.org/10.1007/BF00123369