Résumé
Objectif
L’étude MecoExpo menée en Picardie, région agricole utilisatrice de pesticides, visait à mettre en relation l’exposition parentale et l’imprégnation foetale aux pesticides avec les paramètres cliniques du développement fœtal relevés à la naissance.
Matériel et méthode
L’exposition parentale aux pesticides a été évaluée par un questionnaire et l’imprégnation foetale aux pesticides, pour la première fois en France, par un dosage dans le méconium.
Résultats
Neuf cent quatre-vingt-treize couples mère-enfant ont été inclus. Une association entre exposition professionnelle maternelle aux pesticides et augmentation du risque de restriction de croissance fœtale pour le poids de naissance a été observée. Une augmentation du risque de prématurité chez les enfants issus de père travaillant dans un secteur exposé aux pesticides a également été relevée. Quatre-vingt-cinq pour cent des nouveau-nés présentaient au moins un des pesticides recherchés dans leur méconium. Les pesticides observés le plus fréquemment sont les métabolites des organophosphorés et ceux des carbamates, deux grandes familles d’insecticides dispersés sur les grandes cultures.
Conclusion
Des associations entre l’exposition professionnelle maternelle et paternelle et les paramètres cliniques à la naissance ont été observées. La recherche des pesticides a été réalisée pour la première fois en France dans le méconium de nouveau-nés.
Abstract
Background
The MecoExpo study was conducted in Picardy, an agricultural region where pesticides are used. This study was designed to evaluate the relationship between parental and fetal exposure to pesticides. Neonatal anthropomorphic parameters were compared to parental pesticide exposure during pregnancy.
Materials and methods
Parental exposure to pesticides was assessed by means of a validated questionnaire. In utero fetal exposure was assessed for the first time in France by means of neonatal meconium assays.
Results
Nine-hundred and ninety-three mother-newborn pairs were included. A significant relationship was observed between maternal occupational exposure to pesticides and low birth weight for gestational age. An association was also observed between preterm birth and paternal exposure to pesticides. At least one pesticide was detected on meconium screening in 85% of newborns. The pesticides most frequently detected were organophosphorus and carbamate metabolites. These pesticides are commonly used for extensive field treatments in Picardy.
Conclusion
A significant relationship was observed between maternal and paternal occupational exposure to pesticides and neonatal anthropomorphic parameters. Positive screening for pesticides in the meconium of newborns was assessed for the first time in France.
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Références
Steenland K, Jenkins B, Ames RG, et al (1994) Chronic neurological sequelae to organophosphate pesticide poisoning. Am J Public Health 84:731–736
Bradman A, Whyatt RM (2005) Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children’s Study: a review of monitoring and measurement methodologies. Environ Health Perspect 113:1092–1099
Grandjean P, Harari R, Barr DB, Debes F (2006) Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Pediatrics 117:e546–e556
Handal AJ, Harlow SD, Breilh J, Lozoff B (2008) Occupational exposure to pesticides during pregnancy and neurobehavioral development of infants and toddlers. Epidemiology 19:851–859
Holene E, Nafstad I, Skaare JU, Sagvolden T (1998) Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126. Behav Brain Res 94:213–224
Rosenstein L, Chernoff N (1978) Spontaneous and evoked EEG changes in perinatal rats following in utero exposure to Baygon: a preliminary investigation. Bull Environ Contam Toxicol 20:624–632
Young JG, Eskenazi B, Gladstone EA, et al (2005) Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 26:199–209
Jurewicz J, Hanke W (2008) Prenatal and childhood exposure to pesticides and neurobehavioral development: review of epidemiological studies. Int J Occup Med Environ Health 21:121–132
Hong Z, Günter M, Randow FF (2002) Meconium: a matrix reflecting potential fetal exposure to organochlorine pesticides and its metabolites. Ecotoxicol Environ Saf 51:60–64
Ostrea EM Jr, Romero A, Knapp DK, et al (1994) Postmortem drug analysis of meconium in early-gestation human fetuses exposed to cocaine: clinical implications. J Pediatr 124:477–479
Ostrea EM Jr, Bielawski DM, Posecion NC Jr, et al (2008) A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides. Environ Res 106:277–283
Tsatsakis AM, Tzatzarakis MN, Koutroulakis D, et al (2009) Dialkyl phosphates in meconium as a biomarker of prenatal exposure to organophosphate pesticides: a study on pregnant women of rural areas in Crete, Greece. Xenobiotica 39:364–373
Berton T, Mayhoub F, Chardon K, et al (2013) Development of an analytical strategy based on UPLC-MS/MS for the measurement of different classes of pesticides and theirs metabolites in meconium: application and characterisation of fetal exposure in France. Environ Res (en révision)
Mamelle N, Boniol M, Rivière O, et al (2006) Identification of newborns with fetal growth restriction (FGR) in weight and/or length based on constitutional growth potential. Eur J Pediatr 165:717–725
Savitz DA, Whelan EA, Kleckner RC (1989) Self-reported exposure to pesticides and radiation related to pregnancy outcome: results from National Natality and Fetal Mortality Surveys. Public Health Rep 104:473–477
Wohlfahrt-Veje C, Main KM, Schmidt IM, et al (2011) Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study. Environ Health 10:79
Petit C, Blangiardo M, Richardson S, et al (2012) Association of environmental insecticide exposure and fetal growth with a Bayesian model including multiple exposure sources: the PELAGIE mother-child cohort. Am J Epidemiol 175:1182–1190
Berkowitz GS, Wetmur JG, Birman-Deych E, et al (2004) In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 112:388–391
Whyatt RM, Camann D, Perera FP, et al (2005) Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol 206:246–254
Whyatt RM, Garfinkel R, Hoepner LA, et al (2009) A biomarker validation study of prenatal chlorpyrifos exposure within an innercity cohort during pregnancy. Environ Health Perspect 117:559–567
Bielawski D, Ostrea EM, Posecion NC, et al (2005) Detection of several classes of pesticides and metabolites in meconium by gas chromatography-mass spectrometry. Chromatographia 62:623–629
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D’après la communication CO087, lauréate du prix de la Société française de médecine périnatale, congrès 2013 de la SFMP.
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Tourneux, P., Mayhoub, F., Haraux, E. et al. Cohorte MecoExpo : utilisation du méconium pour estimer l’exposition in utero aux pesticides des nouveau-nés en Picardie. Rev. med. perinat. 6, 122–133 (2014). https://doi.org/10.1007/s12611-014-0277-5
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DOI: https://doi.org/10.1007/s12611-014-0277-5