Abstract
Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Sauer, J.M., Kleensang, A., Peitsch, M.C. et al. Advancing Risk Assessment through the Application of Systems Toxicology. Toxicol Res. 32, 5–8 (2016). https://doi.org/10.5487/TR.2016.32.1.005
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DOI: https://doi.org/10.5487/TR.2016.32.1.005