Abstract
Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb2O3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb2O3 nanoparticles for use as a powerful CT contrast agent.
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Ghazanfari, A., Marasini, S., Tegafaw, T. et al. X-ray Attenuation Properties of Ultrasmall Yb2O3 Nanoparticles as a High-Performance CT Contrast Agent. J. Korean Phys. Soc. 74, 286–291 (2019). https://doi.org/10.3938/jkps.74.286
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DOI: https://doi.org/10.3938/jkps.74.286