Abstract
Experiments with cells enriched in stable magnesium isotopes, magnetic 25Mg or nonmagnetic 24Mg and 26Mg, are carried out. It is revealed that adaptation of bacteria E. coli to the growth media enriched in magnetic 25Mg proceeds faster as compared to the growth media enriched in nonmagnetic magnesium isotopes. In experiments with another commonly accepted cell model, S. cerevisiae yeast, it is revealed that the rate constant of postradiation recovery of the cells after UV irradiation is two times higher for cells enriched in 25Mg than for cells enriched in the nonmagnetic isotope. In collaboration with Ukrainian colleagues from the Palladin Institute of Biochemistry, the effects of different isotopes of magnesium on ATPase activity of myosin isolated from myometrium are studied. It is found that the rate of the enzymatic hydrolysis of ATP for 25Mg is 2.0–2.5 times higher as compared to nonmagnetic isotopes 24Mg and 26Mg. Some possible mechanisms of magnetic isotope effects (nuclear spin catalysis) in biological objects are discussed.
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References
Encyclopedia of Nuclear Magnetic Resonance, Grant, D.M. and Harris, R.K., Eds., Chichester Wiley, 1996.
Bogatyrenko, T.N., Kudryashova, E.A. Tumanova, L.V. and Koltover, V.K., Proc. V Int. Congress on Low and Superlow Fields and Radiations in Biology and Medicine, St. Petersburg, 2009, p. 92.
Koltover, V.K., Shevchenko, U.G., Avdeeva, L.V., Roiba, E.A., Berdinskii, V.L., and Kudryashova, E.A., Dokl. Biochem. Biophys., 2012, vol. 442, no. 1, p. 12.
Koltover, V., Kutlakhmedov, Y., and Grodzinsky, D., Mol. Biol. Cell, 2011, vol. 22, p. 441.
Koltover, V.K., Korolev, V.G., and Kutlakhmedov, Y.A., Antioxidant prophylaxis of radiation stress, in Ionizing Radiation: Applications, Sources, and Biological Effects, New York: Nova Science, 2012, p. 117.
Koltover, V.K., Labyntseva, R.D., Karandashev, V.K., and Kosterin, S.O., Biophysics, 2016, vol. 61, no. 2, p. 200.
Nelson, D.L. and Cox, M.M., Lehninger Principles of Biochemistry, New York Freeman, 2008.
Gus’kova, R.A., Vilenchik, M.M., and Koltover, V.K., Biofizika, 1980, vol. 25, no. 1, p. 102.
Bartha, R. and Ordal, E.J., J. Bacteriol., 1965, vol. 89, p. 1015.
Enoch, K.G. and Lester, R.L., J. Bacteriol., 1972, vol. 110, p. 1032.
Zel’dovich, Ya.B., Buchachenko, A.L, and Frankevich, E.L., Phys.-Usp., 1988, vol. 31, no. 5, p. 385.
Buchachenko, A.L., Novaya izotopiya v khimii i biokhimii (New Isotopy in Chemistry and Biochemistry), Moscow, 2007.
Buchachenko, A.L., J. Phys. Chem. B, 2013, vol. 117, p. 2231.
Vol’kenshtein, M.V., Obshchaya biofizika (General Biophysics), Moscow, 1978.
Kiani, F.A. and Fischer, S., Proc. Natl. Acad. Sci. U. S. A., 2014, vol. 111, no. 29, p. 2947.
Blumenfeld, L.A. and Koltover, V.K., Mol. Biol., 1972, vol. 6, no. 1, p. 130.
Koltover, V.K., Russ. Chem. Bull., 2014, no. 5, p. 1029.
Badylevich, M.V., Kveder, V.V., Orlov, V.I., and Ossipyan, Yu.A., Phys. Status Solidi C, 2005, vol. 2, no. 6, p. 1869.
Tikhonov, V.I. and Volkov, A.A., Science, 2001, vol. 296, p. 2363.
Scolnik, Y., Portnaya, I., Cogan, U., Tal, S., Haimovitz, R., Fridkin, M., Elitzur, A.C., Deamer, D.W., and Shinitzky, M., Phys. Chem. Chem. Phys., 2006, no. 3, p. 333.
Buchachenko, A.L., Kuznetsov, D.A., Arkhangel’skii, S.B., Orlova, M.A., Markaryan, A.A., Berdieva, A.G., and Khasigov, P.Z., Dokl. Biochem. Biophys., 2004, vol. 396, no. 1, p. 197.
Nohl, H., Koltover, V., and Stolze, K, Free Radical Res. Commun., 1993, vol. 18, no. 3, p. 127.
Crotty, D., Silkstone, G., Poddar, S., Ranson, R., Prina-Mello, A., Wilson, M.T., and Coey, J.M.D., Proc. Nat. Acad. Sci. U. S. A., 2012, vol. 109, p. 1437.
Buchachenko, A.L., Orlov, A.P., Kuznetsov, D.A., and Breslavskaya, N.N., Nucleic Acids Res., 2013, vol. 41, no. 17, p. 8300.
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Original Russian Text © L.V. Avdeeva, V.K. Koltover, 2016, published in Vestnik Moskovskogo Universiteta. Khimiya, 2016, No. 3, pp. 145–153.
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Avdeeva, L.V., Koltover, V.K. Nuclear spin catalysis in living nature. Moscow Univ. Chem. Bull. 71, 160–166 (2016). https://doi.org/10.3103/S0027131416030020
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DOI: https://doi.org/10.3103/S0027131416030020