Abstract
Liquid chromatography coupled with mass spectrometry (LC-MS) is one of the most prominent analytical techniques due to its inherent selectivity and sensitivity. LC-MS is currently the first choice for high-throughput bioanalysis due to the advancements in MS instruments and the analytical software. Based on this situation, we are developing various types of derivatization reagents, including chiral reagents for MS and/or MS/MS detection. These developed reagents are adopted for the detection of biomarker candidates related to diseases. The biomarker candidates include not only achiral molecules, but also chiral ones. Although determining the already-identified chiral molecules is relative easy, it is very difficult to identify and/or determine unknown enantiomer(s) in real samples. To solve this difficulty, we proposed a new strategy to identify unknown enantiomeric biomarkers related to diseases. This review paper deals with the development of derivatization reagents for amines and carboxylic acids in LC-MS analysis and their application to bioanalysis.
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Acknowledgments
I would like to express my sincere gratitude to all of the collaborators who contributed to this research. I also thank all the members, including the graduate and undergraduate students in my laboratory. These studies were financially supported by Funds, and Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS).
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Toyo’Oka, T. Derivatization-based High-throughput Bioanalysis by LC-MS. ANAL. SCI. 33, 555–564 (2017). https://doi.org/10.2116/analsci.33.555
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DOI: https://doi.org/10.2116/analsci.33.555