Abstract
We demonstrated the complementary use of inductively coupled plasma–mass spectrometry (ICP-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) for the analysis of Se-containing compounds, such as selenate, selenomethionine (SeMet), and trimethylselenonium ion (TMSe), found in biological samples. The sensitivity of ESI-Q-TOF-MS for Se-containing compounds was strongly dependent on the chemical species. ICP-MS exhibited higher sensitivity than ESI-Q-TOF-MS, and had no species dependency. On the other hand, ESI-Q-TOF-MS enabled easy and robust identification of Se-containing compounds.
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Acknowledgments
This study was supported by JSPS KAKENHI Grants (Nos. 25870739 to Y. A. and 26293030 to Y. O.) and the MEXTSupported Program for Strategic Research Foundation at Private Universities (2013-2017). We also thank Takeda Science Foundation, Japan for financial support.
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Anan, Y., Nakajima, G. & Ogra, Y. Complementary Use of LC-ICP-MS and LC-ESI-Q-TOF-MS for Selenium Speciation. ANAL. SCI. 31, 561–564 (2015). https://doi.org/10.2116/analsci.31.561
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DOI: https://doi.org/10.2116/analsci.31.561