Abstract
For the first time, we report on a copper nanoclusters based fluorescence sensor for hemoglobin (Hgb). The aggregation-induced quenching of tannic acid capped copper nanoclusters’ (TACuNCs) fluorescence by a Hgb-H2O2 mixture that mimics the Fenton’s reagent is used here for the selective determination of Hgb. It is possible to effectively determine Hgb using this sensitive and cost-effective sensor in the linear range of 5.0 × 10−8 to 4.0 × 10−9 M with a detection limit of 5.6 × 10−10 M. The practical utility of the sensor is evident from the good recovery values obtained from Hgb spiked with artificial blood serum.
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Acknowledgements
The authors, Sonia Sam, Sanu K. Anand and Manna Rachel Mathew, would like to acknowledge Council of Scientific and Industrial Research, India, Cochin University of Science and Technology and University Grants Commission, India respectively for the research fellowship.
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Sam, S., Anand, S.K., Mathew, M.R. et al. Tannic Acid Capped Copper Nanoclusters as a Cost-Effective Fluorescence Probe for Hemoglobin Determination. ANAL. SCI. 37, 599–603 (2021). https://doi.org/10.2116/analsci.20P322
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DOI: https://doi.org/10.2116/analsci.20P322