Abstract
Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.
概要
三级淋巴结构主要在包括肿瘤在内的慢性炎症部位的非淋巴组织中发展形成。这一异位形成的淋巴结构主要包含趋化因子招募而来的B细胞、T细胞以及起支持作用的树突状细胞(DC)。成熟的三级淋巴结构有利于适应性免疫细胞的发育与互作,进而增强其抗肿瘤免疫应答。但该抗肿瘤效应取决于三级淋巴结构的具体定位以及成熟阶段。目前有越来越多的研究表明三级淋巴结构的抗肿瘤机制将有助于新型免疫疗法的探索。现有的治疗策略研究方案包括联合瘤内三级淋巴结构与药物治疗或诱导瘤内三级淋巴结构的形成,从而实现提升肿瘤治疗疗效和改善肿瘤患者预后的目的。
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Acknowledgments
This work was supported by the Zhejiang Provincial Key Project of Research and Development (No. 2019C03043), the National Natural Science Foundation of China (Nos. 32030035, 31870874, 32000623, and 32100693), and the Zhejiang Provincial Natural Science Foundation (No. LZ21C080001) of China.
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Chen, J., Chen, J. & Wang, L. Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes. J. Zhejiang Univ. Sci. B 23, 812–822 (2022). https://doi.org/10.1631/jzus.B2200174
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DOI: https://doi.org/10.1631/jzus.B2200174