Abstract
Deuterated compounds are important in drug discovery and development, e.g., to prepare the so-called stable isotopically labeled internal standards. However, their preparation can be challenging, and its scalability could be difficult with regard to safety aspects. Herein, we report the first continuous-flow iridium(I)-catalyzed ortho-directed hydrogen-deuterium exchange reaction in microreactors. An immobilized iridium(I) catalyst was loaded in continuous- flow microreactors, such as continuous stirred tank reactors and packed-bed reactors. Best results were obtained in a packed-bed reactor allowing deuterium labeling up to M +7.
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Habraken, E.R.M., Haspeslagh, P., Vliegen, M. et al. Iridium(I)-Catalyzed Ortho-Directed Hydrogen Isotope Exchange in Continuous-Flow Reactors. J Flow Chem 5, 2–5 (2015). https://doi.org/10.1556/JFC-D-14-00033
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DOI: https://doi.org/10.1556/JFC-D-14-00033