Abstract
Phosphoinositides are minor phospholipids of cytosolic membrane surface involved in the regulation of vital cellular processes, including membrane trafficking, cytoskeletal dynamics and cell signaling. This regulation lies in their ability to control the subcellular localization and activity of different cytosolic (peripheral) effector proteins bearing phosphoinositide binding domains. However, the detailed molecular mechanisms by which phosphoinositides (and probably other phospholipids) may participate in the regulation of cellular functions remain the subject of debate. This review discusses the general features of the functioning of phosphoinositide system as an organizer and integrator of intracellular events.
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Original Russian Text © Yu.N. Orlov, 2015, published in Biologicheskie Membrany, 2015, Vol. 32, No. 3, pp. 151–167.
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Orlov, Y.N. Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes. Biochem. Moscow Suppl. Ser. A 9, 145–160 (2015). https://doi.org/10.1134/S1990747815020166
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DOI: https://doi.org/10.1134/S1990747815020166