Abstract
Infectious diseases at early ages are often followed by impairments in cognitive functions in children and adolescents. A possible mechanism of these impairments is an altered production of proteins that are involved in the regulation of neuroplasticity in brain cells. One of these proteins is the basic fibroblast growth factor (FGF2). In the present study, we examined the behavior in the “open field” test and FGF2 mRNA production in the medial prefrontal cortex, ventral and dorsal hippocampus, and amygdala of 22-and 23-day-old rats that were injected with bacterial lipopolysaccharide at a dose of 25 µg/kg on days 14, 16, and 18 after birth. We observed decreased exploratory activity and increased static movement compared to the control animals that were injected with a pyrogen-free physiological solution. Impaired behavior was associated with the lower expression of the Fgf2 gene in cells of the medial prefrontal cortex compared to that observed in the intact rats.
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Original Russian Text © E.A. Veniaminova, O.E. Zubareva, 2015, published in Neirokhimiya, 2015, Vol. 32, No. 2, pp. 153–159.
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Veniaminova, E.A., Zubareva, O.E. The changes in exploratory behavior and Fgf2 gene expression in cells of the rat brain after the early postnatal administration of bacterial lipopolysaccharide. Neurochem. J. 9, 127–132 (2015). https://doi.org/10.1134/S1819712415020105
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DOI: https://doi.org/10.1134/S1819712415020105