Abstract
The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. For this purpose, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of actomyosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain and does not depend on the processes of cross-bridges formation.
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Original Russian Text © I.O. Petrova, S.A. Tyganov, T.M. Mirzoev, A.K. Tsaturyan, I.B. Kozlovskaya, B.S. Shenkman, 2018, published in Doklady Akademii Nauk, 2018, Vol. 481, No. 3.
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Petrova, I.O., Tyganov, S.A., Mirzoev, T.M. et al. Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?. Dokl Biochem Biophys 481, 205–207 (2018). https://doi.org/10.1134/S1607672918040075
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DOI: https://doi.org/10.1134/S1607672918040075