Abstract
Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH2, dipeptide Ac-RR-NH2, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH2 upon interaction with the outer membrane of the nociceptive neuron decreases the Zeff value of the activation gating system of Nav1.8 channels. Thus, the tripeptide Ac-RER-NH2 can be considered as a new effective and safe analgesic.
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Original Russian Text © T.N. Shelykh, I.V. Rogachevsky, A.D. Nozdrachev, O.S. Veselkina, S.A. Podzorova, B.V. Krylov, V.B. Plakhova, 2016, published in Doklady Akademii Nauk, 2016, Vol. 466, No. 6, pp. 734–737.
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Shelykh, T.N., Rogachevsky, I.V., Nozdrachev, A.D. et al. Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide. Dokl Biochem Biophys 466, 77–80 (2016). https://doi.org/10.1134/S1607672916010191
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DOI: https://doi.org/10.1134/S1607672916010191