Abstract
thyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate was synthesized by the Gewald reaction of 2-acetyl-1,4-benzodioxane with ethyl 2-cyanoacetate and sulfur in the presence of diethylamine. The product was used to synthesize a series of amido ester derivatives with various pharmacophoric fragments. The antihypoxic properties of the synthesized amido esters were investigated.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances, 2011, WHO.
Patel, A.A. and Mehta, G.A., Der Pharma Chem., 2010, vol. 2, p. 215.
Mishra, R., Jha, K.K., Kumar, S., and Tomer, I., Der Pharma Chem., 2011, vol. 3, p. 38.
Wardakhan, W.W., Abdel-Salam, O.M.E., and Elmegeed, G.A., Acta Pharm., 2008, vol. 58, p. 1. doi https://doi.org/10.2478/v10007-007-0041-5
Wilcke, M., Walum, E., and Wikström, P., Patent Appl. no. WO2013135803 A1, 2013
Vartanyan, S.O., Avakyan, A.S., Sargsyan, A.B., Arutyunyan, S.A., Noravyan, O.S., and Tsatinyan, A.S., Russ. J. Org. Chem., 2016, vol. 52, p. 244. doi https://doi.org/10.1134/S1070428016020159
Shirinyan, E.A., Martirosyan, O.M., Arutyunyan, S.A., Atayan, T.K., Fiziol. Zh. SSSR, 1990, vol. 76, p. 1197.
Author information
Authors and Affiliations
Corresponding author
Additional information
Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 5, pp. 690–693.
Rights and permissions
About this article
Cite this article
Vardanyan, S.O., Aghekyan, A.A., Avagyan, A.S. et al. Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene. Russ J Org Chem 55, 598–601 (2019). https://doi.org/10.1134/S1070428019050038
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070428019050038